Altered neural oscillations underlying visuospatial processing in cerebral visual impairment.
Altered neural oscillations underlying visuospatial processing in cerebral visual impairment.
复制标题
脑视觉障碍中视觉空间处理的神经振荡发生改变。
DOI：
10.1093/braincomms/fcad232
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发表时间：
2023
影响因子：
4.8
通讯作者：
Merabet,LotfiB
中科院分区：
文献类型：
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作者：
Federici,Alessandra;Bennett,ChristopherR;Bauer,CorinnaM;Manley,ClaireE;Ricciardi,Emiliano;Bottari,Davide;Merabet,LotfiB
视觉空间处理缺陷通常在脑视觉障碍的个体中观察到，即使在视力和视野功能完好的情况下也是如此。脑性视觉障碍是一种以脑为基础的视觉障碍，与中枢视觉通路和结构的发育不良有关。然而，在这种情况下，高阶感知障碍的神经生理学基础尚未明确确定，这反过来又限制了开发康复干预措施。使用相结合的眼动跟踪和脑电图记录，我们评估了自然的虚拟现实为基础的任务的视觉搜索的配置文件和性能。参与者与大脑视觉障碍和控制与神经发育指示搜索，定位和固定在一个特定的目标放置在周围的干扰在两个级别的任务难度。我们分析了宽带（4-55 Hz）神经振荡的诱发（锁相）和诱导（非锁相）成分，以揭示视觉空间处理的神经生理学基础。 我们发现，视觉搜索性能受损的大脑视觉障碍相比，对照组（索引的成功率，反应时间和凝视错误的结果）。神经振荡分析显示，无论任务难度如何，早发性诱发θ [4-6 Hz]活动（0.5 s内）均显著减少。 此外，虽然诱导的α活动增加任务难度的控制，这种调制是不存在的大脑视觉障碍组确定一个潜在的神经相关的赤字与视觉搜索和干扰抑制。最后，大脑视觉障碍参与者也显示出持续的诱导伽马反应[30-45 Hz]。 我们的结论是，受损的视觉搜索性能在脑视觉障碍与大范围的神经振荡频率的实质性改变。这包括诱发和诱导成分，表明前馈和反馈处理以及局部和分布式神经处理的参与。
Visuospatial processing deficits are commonly observed in individuals with cerebral visual impairment, even in cases where visual acuity and visual field functions are intact. Cerebral visual impairment is a brain-based visual disorder associated with the maldevelopment of central visual pathways and structures. However, the neurophysiological basis underlying higher-order perceptual impairments in this condition has not been clearly identified, which in turn poses limits on developing rehabilitative interventions. Using combined eye tracking and EEG recordings, we assessed the profile and performance of visual search on a naturalistic virtual reality-based task. Participants with cerebral visual impairment and controls with neurotypical development were instructed to search, locate and fixate on a specific target placed among surrounding distractors at two levels of task difficulty. We analysed evoked (phase-locked) and induced (non-phase-locked) components of broadband (4–55 Hz) neural oscillations to uncover the neurophysiological basis of visuospatial processing. We found that visual search performance in cerebral visual impairment was impaired compared to controls (as indexed by outcomes of success rate, reaction time and gaze error). Analysis of neural oscillations revealed markedly reduced early-onset evoked theta [4–6 Hz] activity (within 0.5 s) regardless of task difficulty. Moreover, while induced alpha activity increased with task difficulty in controls, this modulation was absent in the cerebral visual impairment group identifying a potential neural correlate related to deficits with visual search and distractor suppression. Finally, cerebral visual impairment participants also showed a sustained induced gamma response [30–45 Hz]. We conclude that impaired visual search performance in cerebral visual impairment is associated with substantial alterations across a wide range of neural oscillation frequencies. This includes both evoked and induced components suggesting the involvement of feedforward and feedback processing as well as local and distributed levels of neural processing.