Complementary networks of cortical somatostatin interneurons enforce layer specific control
Complementary networks of cortical somatostatin interneurons enforce layer specific control
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DOI：
10.7554/elife.43696
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发表时间：
2019-03-18
期刊：
影响因子：
7.7
通讯作者：
Adesnik, Hillel
中科院分区：
文献类型：
--
作者：
Naka, Alexander;Veit, Julia;Adesnik, Hillel
新皮质在功能上被组织成层。第四层接收最密集的自下而上的感官输入，而第二/3层和第五层接收可能传达预测信息的自上而下的输入。皮质生长抑素 (SST) 神经元的一个子集，Martinotti 细胞，通过抑制第 2/3 层和第 5 层锥体细胞的顶端树突来控制自上而下的输入，但尚不清楚是否有类似的抑制机制控制第 4 层的活动。利用高精度电路图谱、体内光遗传扰动和单细胞转录分析，我们揭示了小鼠桶状皮层中涉及遗传不同的 SST 亚型的互补电路，这些亚型专门和与不同层中的兴奋性细胞相互互连：Martinotti 细胞与第 2/3 层和第 5 层连接，而非 Martinotti 细胞与第 4 层连接。通过实施层特异性抑制，这些并行的 SST 子网络可以独立调节自下而上和自上而下输入之间的平衡。
The neocortex is functionally organized into layers. Layer four receives the densest bottom up sensory inputs, while layers 2/3 and 5 receive top down inputs that may convey predictive information. A subset of cortical somatostatin (SST) neurons, the Martinotti cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in layers 2/3 and 5, but it is unknown whether an analogous inhibitory mechanism controls activity in layer 4. Using high precision circuit mapping, in vivo optogenetic perturbations, and single cell transcriptional profiling, we reveal complementary circuits in the mouse barrel cortex involving genetically distinct SST subtypes that specifically and reciprocally interconnect with excitatory cells in different layers: Martinotti cells connect with layers 2/3 and 5, whereas non-Martinotti cells connect with layer 4. By enforcing layer-specific inhibition, these parallel SST subnetworks could independently regulate the balance between bottom up and top down input.