Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity
Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity
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DOI：
10.1016/j.jneuroim.2010.09.023
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Dressel, Alexander
中科院分区：
文献类型：
--
作者：
Vogelgesang, Antje;Dressel, Alexander
中风可能伴随免疫学后果，包括局部自身免疫和外周免疫抑制。由于血脑屏障受到干扰，免疫系统的细胞可以直接进入脑实质。在此，局部自身免疫有助于病变形成，并且在实验性中风中，抑制这种免疫应答已被证明是有益的。然而，最近，中风已被证明也会引起严重的外周免疫抑制，易患随后的细菌感染，损害临床outcome.Here，我们总结了目前的知识缺血性中风的免疫后果，并将讨论这些研究结果的影响，我们的理解多发性硬化症的免疫发病机制。(C)2010 Elsevier B.V.保留所有权利。
Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, inhibition of this immune response has been shown to be beneficial. More recently, however, stroke has been shown to also induce severe peripheral immune suppression which predisposes for subsequent bacterial infections that impair the clinical outcome.Here we summarize current knowledge on the immunological consequences of ischemic stroke and will discuss implications of these findings for our understanding of the immunopathogenesis of Multiple Sclerosis. (C) 2010 Elsevier B.V. All rights reserved.