Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
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DOI：
10.1016/j.ijantimicag.2020.105949
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发表时间：
2020-07-01
影响因子：
10.8
通讯作者：
Raoult, Didier
中科院分区：
文献类型：
--
作者：
Gautret, Philippe;Lagier, Jean-Christophe;Raoult, Didier
背景：氯喹和羟氯喹已被发现对SARS-CoV-2有效，并报告对中国COV-19患者有效。我们评估羟基氯喹对呼吸道病毒载量的影响。患者和方法：法国确诊的COVID-19患者被纳入3月初至3月16日的单臂方案，每天接受600 mg羟基氯喹，并在医院环境中每天测试鼻咽拭子中的病毒载量。根据他们的临床表现，阿奇霉素被添加到治疗中。来自另一个中心的未治疗患者和拒绝方案的病例被纳入作为阴性对照。在入选后第6天存在和不存在病毒被视为终点。6例患者无症状，22例有上呼吸道感染症状，8例有下呼吸道感染症状。本研究中治疗了20例患者，与对照组相比，在入选后第6天病毒携带率显著降低，并且平均携带时间比文献中报道的未经治疗的患者要短得多。结论：尽管样本量较小，但我们的调查显示，羟氯喹治疗与COVID-19患者的病毒载量减少/消失显著相关，阿奇霉素加强了其效果。(C)2020由Elsevier B. V.出版
Background: Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.Patients and methods: French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.Results: Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.Conclusion: Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. (C) 2020 Published by Elsevier B.V.