A brief history of nearly EV-erything - The rise and rise of extracellular vesicles.
A brief history of nearly EV-erything - The rise and rise of extracellular vesicles.
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DOI：
10.1002/jev2.12144
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发表时间：
2021-12
影响因子：
16
通讯作者：
Carter DRF
中科院分区：
文献类型：
--
作者：
Couch Y;Buzàs EI;Di Vizio D;Gho YS;Harrison P;Hill AF;Lötvall J;Raposo G;Stahl PD;Théry C;Witwer KW;Carter DRF
细胞外囊泡（EV）是由细胞释放到细胞外空间的小的载物囊泡。在过去的二十年里，电动汽车领域呈指数级增长;这种增长是因为人们意识到电动汽车不仅仅是一些人最初提出的废物处理系统，而且还是一种复杂的细胞间通信机制。事实上，EV已被证明可以在细胞之间转移功能性货物，并可以影响几个生物过程。这些小的生物颗粒在疾病中也被解除管制。当我们接近第一次实验的75周年之际，电动汽车在不知不觉中被隔离，似乎是正确的评估和回顾该领域是如何开始的，并且已经爆炸到目前的状态。在这里，我们回顾了早期实验，总结了推动该领域发展的关键发现，描述了有组织的电动汽车社区的发展，讨论了该领域的现状，并确定了需要解决的关键挑战。
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell‐to‐cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed.
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影响因子：
6.5
作者：
CRAWFORD, N
通讯作者：
CRAWFORD, N
影响因子：
3.1
作者：
Colino, Jesus;Snapper, Clifford M.
通讯作者：
Snapper, Clifford M.
DOI：
10.1165/rcmb.2003-0238oc
发表时间：
2004-07-01
影响因子：
6.4
作者：
Bard, MP;Hegmans, JP;Lambrecht, BN
通讯作者：
Lambrecht, BN
DOI：
10.1016/s0022-5320(71)80003-5
发表时间：
1971-01-01
期刊：
JOURNAL OF ULTRASTRUCTURE RESEARCH
影响因子：
--
作者：
AARONSON, S;BEHRENS, U;HAINES, TH
通讯作者：
HAINES, TH
影响因子：
5.4
作者：
Dragovic, Rebecca A.;Gardiner, Christopher;Brooks, Alexandra S.;Tannetta, Dionne S.;Ferguson, David J. P.;Hole, Patrick;Carr, Bob;Redman, Christopher W. G.;Harris, Adrian L.;Dobson, Peter J.;Harrison, Paul;Sargent, Ian L.
通讯作者：
Sargent, Ian L.