Relation between mental stress-induced prefrontal cortex activity and skin conditions: A near-infrared spectroscopy study
Relation between mental stress-induced prefrontal cortex activity and skin conditions: A near-infrared spectroscopy study
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DOI：
10.1016/j.brainres.2007.09.058
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发表时间：
2007-12-12
期刊：
影响因子：
2.9
通讯作者：
Sakatani, Kaoru
中科院分区：
文献类型：
--
作者：
Tanida, Masahiro;Katsuyama, Masako;Sakatani, Kaoru
虽然心理压力会影响皮肤状况，但其神经生理机制尚不清楚。在这项研究中，我们评估了皮肤状况和左/右不对称的前额叶皮层（PFC）活动在精神应激任务的关系，因为最近的研究表明，右PFC占主导地位的调节应激反应系统，包括下丘脑-垂体-肾上腺（HPA）轴。使用近红外光谱，我们测量了正常成年人在心算任务期间双侧PFC中血红蛋白浓度的变化，并评估了侧化评分（即，[（右-左）/（右+左）]）的氧合血红蛋白浓度变化。应激的诱发通过状态-特质焦虑量表（STAI）和心率进行验证。在任务前测量面部皮肤中的皮脂水平和痤疮丙酸杆菌种群。该任务显著增加了STAI-II评分（p=0.00079）和心率（p=0.0000049）。任务期间，双侧PFC中的氧合血红蛋白浓度增加，与脱氧血红蛋白浓度降低相关。氧合血红蛋白浓度变化的偏侧性得分与任务前面部皮肤中的皮脂水平（r=+0.50，p =0.026）和痤疮丙酸杆菌种群（r=+0.49，p =0.029）正相关。心率变化与氧合血红蛋白浓度变化的偏侧性评分呈显著正相关（r=+0.54，p =0.015）。这些结果表明，在面部皮肤中具有较高皮脂水平和较高痤疮丙酸杆菌群体的受试者在精神应激任务期间具有右优势PFC活性，并且表明这些受试者对与应激反应系统（包括HPA轴系统）的过度活跃相关的精神应激敏感。(C)2007 Elsevier B. V.保留所有权利。
Although psychological stress affects skin condition, the neurophysiological mechanism involved is unclear. In this study, we evaluated the relationship between skin condition and left/right asymmetry in prefrontal cortex (PFC) activity during mental stress tasks since recent studies have suggested that the right PFC dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (HPA) axis. Using near-infrared spectroscopy, we measured hemoglobin concentration changes in the bilateral PFC during a mental arithmetic task in normal adults and evaluated the laterality scores (i.e., [(right-left)/(right+left)]) of oxyhemoglobin concentration changes. Elicitation of stress was verified by the State-Trait Anxiety Inventory (STAI) and heart rate. The sebum levels and Propionibacterium acnes populations in the facial skin were measured before the task. The task significantly increased the STAI-II scores (p=0.00079) and heart rate (p=0.0000049). The oxyhemoglobin concentration increased in the bilateral PFC during the task, associated with a decrease in deoxyhemoglobin concentration. The laterality scores of oxyhemoglobin concentration changes were positively correlated with sebum levels (r=+0.50, p=0.026) and P. acnes populations (r=+0.49, p=0.029) in the facial skin before the task. There was a significant positive correlation between heart rate changes and the laterality scores of oxyhemoglobin concentration changes (r=+0.54, p=0.015). These results demonstrate that the subjects with higher sebum levels and higher P. acnes populations in the facial skin have a right dominant PFC activity during a mental stress task and suggest that such subjects are sensitive to mental stress associated with hyperactivity of the stress response system, including the HPA axis system. (C) 2007 Elsevier B.V. All rights reserved.