A research agenda for malaria eradication: vaccines.
A research agenda for malaria eradication: vaccines.
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DOI：
10.1371/journal.pmed.1000398
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发表时间：
2011-01-25
期刊：
影响因子：
15.8
通讯作者：
malERA Consultative Group on Vaccines
中科院分区：
文献类型：
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作者：
malERA Consultative Group on Vaccines
消灭疟疾研究议程疫苗协商小组提出了一项研究和发展议程，以提供制造可在消灭疟疾期间使用的疫苗的工具。疫苗可能是根除疟疾努力的一个关键组成部分。目前开发疟疾疫苗的尝试主要集中在恶性疟原虫上，并旨在降低发病率和死亡率。继续支持这些努力至关重要，但如果要将疟疾疫苗作为消除或根除疟疾的一系列工具的一部分，它们就需要对疟疾传播产生影响。我们引入了“阻断疟疾传播的疫苗”（VIMT）的概念，其中不仅包括针对性阶段和蚊子阶段的“经典”传播阻断疫苗，还包括对传播有影响的红细胞前期和无性阶段疫苗。VIMT还可以包括靶向载体以破坏蚊子中的寄生虫发育的疫苗。重要的是，如果要实现根除，疟疾疫苗开发工作将需要针对其他疟疾寄生虫物种，特别是间日疟原虫，其中针对催眠虫的新型治疗性疫苗或针对多个阶段的预防性疫苗可能产生巨大影响。一个目标产品简介（TPP）的VIMT提出了一个研究议程，以解决目前的知识差距，并开发必要的工具，设计和开发的VIMT。
The Malaria Eradication Research Agenda (malERA) Consultative Group on Vaccines present a research and development agenda to provide the tools to create vaccines that may be used during malaria eradication. Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity and mortality. Continued support for these efforts is essential, but if malaria vaccines are to be used as part of a repertoire of tools for elimination or eradication of malaria, they will need to have an impact on malaria transmission. We introduce the concept of “vaccines that interrupt malaria transmission” (VIMT), which includes not only “classical” transmission-blocking vaccines that target the sexual and mosquito stages but also pre-erythrocytic and asexual stage vaccines that have an effect on transmission. VIMT may also include vaccines that target the vector to disrupt parasite development in the mosquito. Importantly, if eradication is to be achieved, malaria vaccine development efforts will need to target other malaria parasite species, especially Plasmodium vivax, where novel therapeutic vaccines against hypnozoites or preventive vaccines with effect against multiple stages could have enormous impact. A target product profile (TPP) for VIMT is proposed and a research agenda to address current knowledge gaps and develop tools necessary for design and development of VIMT is presented.