Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits
Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits
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DOI：
10.1161/jaha.118.011630
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发表时间：
2019-05-07
影响因子：
5.4
通讯作者：
Girouard, Helene
中科院分区：
文献类型：
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作者：
Muhire, Gervais;Iulita, M. Florencia;Girouard, Helene
背景-动脉硬化与认知能力下降和痴呆有关;然而，它影响大脑的确切机制仍然不清楚。方法和结果-使用基于颈动脉钙化的小鼠模型，本研究的特征在于可能导致脑退化的机制，由于动脉硬化。在钙化后2周，颈动脉硬化减弱了几个脑区的静息脑血流，包括周围/内嗅皮质、海马和丘脑，通过放射自显影测定（P
Background-Arterial stiffness is associated with cognitive decline and dementia; however, the precise mechanisms by which it affects the brain remain unclear.Methods and Results-Using a mouse model based on carotid calcification this study characterized mechanisms that could contribute to brain degeneration due to arterial stiffness. At 2 weeks postcalcification, carotid stiffness attenuated resting cerebral blood flow in several brain regions including the perirhinal/entorhinal cortex, hippocampus, and thalamus, determined by autoradiography (P