Endoglin expression in early development is associated with vasculogenesis and angiogenesis
Endoglin expression in early development is associated with vasculogenesis and angiogenesis
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DOI：
10.1016/s0925-4773(01)00562-7
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发表时间：
2002-01-01
影响因子：
2.6
通讯作者：
Arthur, HM
中科院分区：
文献类型：
--
作者：
Jonker, L;Arthur, HM
内皮糖蛋白是细胞因子的转化生长因子-β家族的辅助受体，并且是血管生成和心脏发育所需的。通过监测从插入内皮糖蛋白启动子下游的lacZ报告盒的β-半乳糖苷酶表达来分析小鼠胚胎发生期间内皮糖蛋白的表达。表达首先检测到在6.5天后cobligation（dpc）在羊膜褶皱和发育中的尿囊。在7.5和8.5 dpc之间，endoglin在卵黄囊、背主动脉和原始心管的内皮细胞中表达，并且在整个发育中的血管系统的内皮细胞中从9.5到13.5 dpc表达。有趣的是，这种内皮糖蛋白的表达模式几乎与Alk 1的报道相同。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Endoglin is an auxiliary receptor for the transforming growth factor-beta family of cytokines and is required for angiogenesis and heart development. Endoglin expression during mouse embryogenesis was analysed by monitoring beta-galactosidase expression from a lacZ reporter cassette inserted downstream of the endoglin promoter. Expression was first detected at 6.5 days post-coitum (dpc) in the amniotic fold and developing allantois. Between 7.5 and 8.5 dpc, endoglin was expressed in endothelial cells of the yolk sac, dorsal aorta and primitive heart tube, and from 9.5 to 13.5 dpc in endothelial cells throughout the developing vasculature. Interestingly, this pattern of endoglin expression is almost identical to that reported for Alk1. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.