Biology of phospholipase inhibitory proteins.
Biology of phospholipase inhibitory proteins.
复制标题
磷脂酶抑制蛋白的生物学。
DOI：
10.1007/978-1-4613-0651-1_14
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发表时间：
1990
影响因子：
--
通讯作者：
Hirata,A
中科院分区：
文献类型：
--
作者：
Hirata,F;Hirata,A
糖皮质激素被广泛用作对抗各种炎症性疾病和过敏性疾病（包括慢性类风湿性关节炎、红斑狼疮和支气管哮喘）最有效的药物之一。作用机制归因于抗炎作用、免疫抑制作用和抗水肿作用1。在这些作用中，抗炎模式现在与抑制花生四烯酸的释放相关，花生四烯酸是前列腺素（PG）、羟基二十碳四烯酸（HETE）和白三烯的前体，被认为是炎症介质2。由于糖皮质激素对类二十烷酸释放的抑制作用的抗炎作用可以被蛋白质合成和 mRNA 合成的抑制剂阻断3, 4，因此认为进入细胞后，糖皮质激素首先与胞质受体结合，所得复合物被转移到细胞核中以激活特定基因，最终诱导特定蛋白质的合成5。尽管花生四烯酸的关键酶和主要来源仍有待在定量方面确定，但磷脂酶 A2（PLA2）和烷基磷脂已被认为是重要因素 6。因此，表明糖皮质激素至少部分（如果不是全部）通过诱导 PLA2 抑制蛋白 7 的合成来发挥其抗炎作用。
Glucocorticoids are widely used as one of the most efficacious medicines against various inflammatory diseases and allergic diseases including chronic rheumatoid arthritis, lupus erythematosus and bronchial asthma. The mechanism of action is attributed to the anti-inflammatory action, immunosuppressive action and anti-edematous action1. Of these actions, the mode of anti-inflammation is now correlated to the inhibition of release of arachidonic acid, a precursor of prostaglandins (PGs), hydroxyeicosatetraenoic acids (HETEs) and leukotrienes regarded to be inflammatory mediators2. Since the anti-inflammatory action of glucocorticoids with respect to the suppressive effect on the release of eicosanoids can be blocked by inhibitors of protein synthesis as well as mRNA synthesis3, 4, it is conceived that upon entering into a cell, glucocorticoids are first bound to the cytosolic receptor and that the resulting complex is transferred into the nucleus to activate the specific genes, after all, inducing the synthesis of specific proteins5. Although the key enzymes and major sources of arachidonic acid still remain to be established in a quantitative aspect, phospholipase A2(PLA2) and alkylphospholipids have been considered as the important factors6. It is, therefore, suggested that glucocorticoids exhibit their anti-inflammatory action at least partly, if not exclusively, through the induced synthesis of PLA2inhibitory protein(s)7.