Collective dynamics of gastric cancer cells in fluid
Collective dynamics of gastric cancer cells in fluid
复制标题
液体中胃癌细胞的集体动力学
DOI：
10.1103/physreve.104.064402
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发表时间：
2021-12-02
影响因子：
2.4
通讯作者：
Zhang, Huan
中科院分区：
文献类型：
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作者：
Jiang, Jiang;Zeng, Zhikun;Zhang, Huan
胃癌（GC）是最常见的消化系统恶性肿瘤，胃癌细胞（GCC）可以在正常实体组织和淋巴液中迁移。此前，很多研究都集中在细胞在固态时的迁移过程，如组织迁移、粘附和侵袭过程，而对GCC在淋巴液中的迁移过程知之甚少。在当前的研究中，我们研究了 GCC 在体外环境中流体条件下的迁移。我们发现细胞扩散主要是因为它们的细胞活力。因此，尽管淋巴液几乎是静止的，GCC却可以轻松地四处迁移。细胞的动力学也表现出类似于普通非活性玻璃材料的集体玻璃动力学。随着细胞密度的增加，细胞的运动变得更慢，集体动态变得异质，这类似于玻璃材料中的动态异质行为。这些结果将有助于我们更好地了解GCC液相动力学特征，这对于理解淋巴转移机制至关重要。这也可能有助于早期诊断GC淋巴结转移，并为未来的临床治疗提供新的见解。
Gastric cancer (GC) is the most common digestive system malignant cancer, and gastric cancer cells (GCC) can migrate in normal solid tissue and lymphatic fluid. Previously, much research has focused on the migration process when the cells are in the solid condition, such as migration through tissue, adhesion, and invasion processes, while little is known about the migration process of GCC in lymphatic fluid. In the current study, we investigate the migration of GCC in a fluid condition in an in vitro environment. We find that the cells diffuse mainly because of their cell viability. Therefore, despite the fact that lymph fluid is almost quiescent, GCCs can migrate around easily. The dynamics of cells also demonstrate a collective glassy dynamic similar to ordinary inactive glassy materials. As density of the cells increases, the movement of the cells becomes slower, and the collective dynamic becomes heterogeneous, which is similar to the dynamically heterogeneous behavior in glassy materials. The results will help us gain a better knowledge of the characteristics of GCC dynamics in the liquid phase which is crucial for the understanding of the mechanism for lymphatic metastasis. This can also potentially help early diagnosis of lymph node metastasis in GC and provide new insights for future clinical treatment.