Epithelial morphological response to soft hydrogel contact lenses.
Epithelial morphological response to soft hydrogel contact lenses.
复制标题
上皮形态对软水凝胶隐形眼镜的反应。
DOI：
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发表时间：
1985
影响因子：
4.1
通讯作者：
L. W. Chu
中科院分区：
文献类型：
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作者：
J. Bergmanson;C. M. Ruben;L. W. Chu
水凝胶（HEMA）角膜接触镜的厚度增加的猫头鹰猴（Aotus tivergatus）在开放和闭上眼睛的条件下，研究角膜上皮细胞的超微结构反应增加的压力。0.07 mm厚的透镜（Dk/L计算值为4.2-2.2）导致上皮变薄，无水肿。这种变薄是由于表层细胞的损失和剩余细胞的扁平化。无水肿的上皮变薄机制中的因素可能包括缺氧、创伤、眼睑压力和透镜重量。0.4 mm厚的透镜在闭合的眼睛中提供可忽略的气体传输，并且在48小时后，大部分上皮被剥离，而水肿和退行性细胞质变化在存活细胞的区域中是显著的。在这些区域，上皮厚度减少到一层或两层细胞。在所有实验中，基底膜未受到水凝胶接触透镜配戴的损害。除闭眼角膜外，所有角膜均维持上皮神经支配，这一发现与软性接触透镜配戴者良好的角膜接触阈值密切相关。
Hydrogel (HEMA) contact lenses of increased thickness were worn by owl monkeys (Aotus tivergatus) under open and closed eye conditions to study ultrastructurally the corneal epithelial response to increased stress. The 0.07 mm thick lens with a calculated Dk/L of 4.2-2.2 caused an epithelial thinning without oedema. This thinning was due to a loss of superficial cells and a flattening of the remaining ones. Factors in the mechanism of epithelial thinning without oedema may include anoxia, trauma, lid pressure, and lens weight. The 0.4 mm thick lens offers negligible gas transmission in the closed eye, and after 48 hours much of the epithelium was stripped, while oedema and degenerative cytoplasmic changes were prominent in areas of surviving cells. In such areas the thickness of the epithelium was reduced to one or two layers of cells. The basement membrane was in all experiments unharmed by hydrogel contact lens wear. The epithelial innervation was maintained in all corneas except those of the closed eye, and finding correlates well with the good corneal touch threshold in soft contact lens wearers.