Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation
Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation
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DOI：
10.1038/s41598-020-68782-w
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发表时间：
2020-07-17
影响因子：
4.6
通讯作者：
Song, Shuo
中科院分区：
文献类型：
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作者：
Yuan, Bo;Liu, Han-Qing;Song, Shuo
最近，COVID-19康复患者中SARS-CoV-2病毒RNA阳性的复发问题受到更多关注。本文报告了对182例康复者进行医学隔离观察的队列研究。182名患者中有20名（10.99%）被检测为SARS-CoV-2 RNA阳性（再阳性），尽管没有人表现出任何临床症状复发，表明COVID-19对治疗反应良好。年龄在18岁以下的患者的再阳性率高于平均水平，没有重症患者的再检测呈阳性。再阳性和非再阳性之间的性别无显著差异。值得注意的是，大多数重新阳性的人在随后的测试中转为阴性，他们都携带了SARS-CoV-2的抗体。这表明它们可能没有传染性，尽管定期进行SARS-CoV-2 RNA检测和随访以评估传染性仍然很重要。本研究之发现，可为改善康复病患之管理，以及区分不同风险等级之康复病患之后续治疗提供参考。
Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients is receiving more attention. Herein we report a cohort study on the follow-up of 182 recovered patients under medical isolation observation. Twenty (10.99%) patients out of the 182 were detected to be SARS-CoV-2 RNA positive (re-positives), although none showed any clinical symptomatic recurrence, indicating that COVID-19 responds well to treatment. Patients aged under 18 years had higher re-positive rates than average, and none of the severely ill patients re-tested positive. There were no significant differences in sex between re-positives and non-re-positives. Notably, most of the re-positives turned negative in the following tests, and all of them carried antibodies against SARS-CoV-2. This indicates that they might not be infectious, although it is still important to perform regular SARS-CoV-2 RNA testing and follow-up for assessment of infectivity. The findings of this study provide information for improving the management of recovered patients, and for differentiating the follow-up of recovered patients with different risk levels.