The Hippocampus and Memory for "What," "Where,"" and "When"
The Hippocampus and Memory for "What," "Where,"" and "When"
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DOI：
10.1101/lm.73304
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发表时间：
2004-07-01
影响因子：
2
通讯作者：
Eichenbaum, H
中科院分区：
文献类型：
--
作者：
Ergorul, C;Eichenbaum, H
先前的研究表明，非人类动物可能具有一种类似情景记忆的能力，体现在对在“何处”以及“何时”发生的“何事”的记忆中。这些研究没有确定对这种能力至关重要的大脑结构。在此，我们训练大鼠记住单次训练事件，每个事件由在开放场地不同位置呈现的一系列气味组成。额外的评估检测了气味和空间线索对事件顺序判断的各自作用。结果表明，正常大鼠利用空间（“何处”）和嗅觉（“何事”）线索的组合来区分事件发生的“何时”。海马体受损的大鼠无法利用空间和嗅觉线索的组合，尽管探测测试和初始取样行为的证据表明其对空间和气味线索的感知能力以及对这些单个线索的某种形式的记忆能力未受损害。这些发现表明，大鼠在对单次经历的记忆中整合了“何事”“何处”和“何时”的信息，并且海马体对这种能力至关重要。
Previous Studies have indicated that nonhuman animals might have a capacity for episodic-like recall reflected in memory for "what" events that happened "where" and "when". These studies did not identify the brain structures that are critical to this capacity. Here we trained rats to remember single training episodes, each composed of a series of odors presented in different places on an open field. Additional assessments examined the individual contributions of odor and spatial cues to judgments about the order of events. The results indicated that normal rats used a combination of spatial ("where") and olfactory ("what") cues to distinguish "when" events Occurred. Rats with lesions of the hippocampus failed ill using combinations of spatial and olfactory cues, even as evidence from probe tests and initial sampling behavior indicated spared capacities for perception of spatial and odor cues, as well as some form of memory for those individual cues. These findings indicate that rats integrate "what," "where," and "when" information in memory for single experiences, and that the hippocampus is critical to this capacity.