Deficient CD4+ CD25+ T Regulatory Cell Function in Patients With Abdominal Aortic Aneurysms
Deficient CD4+ CD25+ T Regulatory Cell Function in Patients With Abdominal Aortic Aneurysms
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DOI：
10.1161/atvbaha.109.200303
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发表时间：
2010-09-01
影响因子：
8.7
通讯作者：
Xin, Shijie
中科院分区：
文献类型：
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作者：
Yin, Mingdi;Zhang, Jian;Xin, Shijie
越来越多的证据表明，自身免疫反应在腹主动脉瘤（AAA）的发病机制中起重要作用。本研究旨在评估AAA患者外周血CD 4（+）CD 25（+）T调节细胞（TCRs）功能的可能改变，TCRs可能破坏AAA患者的免疫自身耐受。32例健康对照（HC），采用流式细胞术检测CD 4（+）CD 25（+）T淋巴细胞在总CD 4（+）T细胞群中的百分比和FOXP 3的表达。CD 4（+）CD 25（+）Treg群体的频率在组间无显著差异（AAA，5.69 +/- 0.99%; AOD，5.52 +/- 1.13%; HC，5.88 +/- 1.55%; P>0.05）。但AAA患者CD 4（+）CD 25（+）FOXP 3（+）T细胞的频率（2.45 ± 0.57%）明显低于AOD组（3.41 ± 0.72%; P
Objective-Increasing evidence shows that autoimmune response contributes importantly to pathogenesis of abdominal aortic aneurysm (AAA). This work was aimed to assess the possibly altered function of peripheral CD4(+) CD25(+) T regulatory cells (Tregs) that might breakdown immunologic self-tolerance in AAA patients.Methods and Results-Peripheral blood from 22 AAA patients, 11 patients with abdominal aortic atherosclerotic occlusive disease (AOD), and 32 healthy controls (HCs) was analyzed to determine the percentage of CD4(+) CD25(+) Tregs in the total CD4(+) T-cell population and FOXP3 expression by means of flow cytometry. The frequencies of the CD4(+) CD25(+) Treg population were not significantly different between groups (AAA, 5.69 +/- 0.99%; AOD, 5.52 +/- 1.13%; HC, 5.88 +/- 1.55%; P>0.05). However, the frequency of CD4(+) CD25(+) FOXP3(+) T cells in AAA patients (2.45 +/- 0.57%) was significantly lower than that in AOD group (3.41 +/- 0.72%; P