Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies.
Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies.
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DOI：
10.1007/s10654-017-0232-4
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发表时间：
2017-03
影响因子：
13.6
通讯作者：
Vatten LJ
中科院分区：
文献类型：
--
作者：
Aune D;Sen A;Schlesinger S;Norat T;Janszky I;Romundstad P;Tonstad S;Riboli E;Vatten LJ
不同的肥胖测量与房颤风险增加有关，然而，先前的结果仅针对BMI进行了总结。因此，我们对前瞻性研究进行了系统回顾和荟萃分析，以阐明不同肥胖措施与房颤风险之间的关系。检索截止到2016年10月24日的PubMed和Embase数据库。采用随机效应模型计算总相对风险（rr）。纳入了29项独特的前瞻性研究（32篇出版物）。25项研究（83,006例，2,405,381名参与者）纳入了BMI和房颤的分析。摘要RR 1.28(95%置信区间:1.20 - -1.38,I2 = 97%) / 5单元增加BMI, 1.18(95%置信区间:1.12—-1.25,I2 = 73%, n = 5)和1.32(95%置信区间:1.16—-1.51,I2 = 91%, n = 3)每增加10厘米的腰和臀围,分别为1.09(95%置信区间:1.02—-1.16,I2 = 44%, n = 4)每增加0.1单元腰臀比,1.09(95%置信区间:1.02—-1.16,I2 = 94%, n = 4)每增加5公斤脂肪质量,1.10(95%置信区间CI:每增加10%的脂肪百分比0.92-1.33,I2 = 90%, n = 3)，每增加5公斤体重1.10 (95% CI: 1.08 - 1.13, I2 = 74%, n = 10)，每增加5%体重1.08 （95% CI: 0.97-1.19, I2 = 86%, n = 2）。BMI和房颤之间的关系是非线性的，p非线性< 0.0001，BMI越高，相关性越强，然而，即使BMI为22-24，与20相比，风险也会增加。总之，全身脂肪和腹部脂肪以及较高的体脂量增加心房颤动的风险。本文的在线版本（doi:10.1007/s10654-017-0232-4）包含补充材料，仅供授权用户使用。
Different adiposity measures have been associated with increased risk of atrial fibrillation, however, results have previously only been summarized for BMI. We therefore conducted a systematic review and meta-analysis of prospective studies to clarify the association between different adiposity measures and risk of atrial fibrillation. PubMed and Embase databases were searched up to October 24th 2016. Summary relative risks (RRs) were calculated using random effects models. Twenty-nine unique prospective studies (32 publications) were included. Twenty-five studies (83,006 cases, 2,405,381 participants) were included in the analysis of BMI and atrial fibrillation. The summary RR was 1.28 (95% confidence interval: 1.20–1.38, I2 = 97%) per 5 unit increment in BMI, 1.18 (95% CI: 1.12–1.25, I2 = 73%, n = 5) and 1.32 (95% CI: 1.16–1.51, I2 = 91%, n = 3) per 10 cm increase in waist and hip circumference, respectively, 1.09 (95% CI: 1.02–1.16, I2 = 44%, n = 4) per 0.1 unit increase in waist-to-hip ratio, 1.09 (95% CI: 1.02–1.16, I2 = 94%, n = 4) per 5 kg increase in fat mass, 1.10 (95% CI: 0.92–1.33, I2 = 90%, n = 3) per 10% increase in fat percentage, 1.10 (95% CI: 1.08–1.13, I2 = 74%, n = 10) per 5 kg increase in weight, and 1.08 (95% CI: 0.97–1.19, I2 = 86%, n = 2) per 5% increase in weight gain. The association between BMI and atrial fibrillation was nonlinear, p nonlinearity < 0.0001, with a stronger association at higher BMI levels, however, increased risk was observed even at a BMI of 22–24 compared to 20. In conclusion, general and abdominal adiposity and higher body fat mass increase the risk of atrial fibrillation. The online version of this article (doi:10.1007/s10654-017-0232-4) contains supplementary material, which is available to authorized users.