Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress
Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress
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DOI：
10.1016/j.brainres.2010.03.006
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发表时间：
2010-05-06
期刊：
影响因子：
2.9
通讯作者：
Kimura, Akihisa
中科院分区：
文献类型：
--
作者：
Imbe, Hiroki;Okamoto, Keiichiro;Kimura, Akihisa
在本研究中，我们研究了在反复被迫游泳应激后，福尔马林诱发的有害行为是否需要来自吻侧腹内侧髓质（RVM）的下行促进。大鼠进行强迫或假游应激3 d。最后一次应激后24h，两组小鼠对有害热刺激的戒断潜伏期和对冯氏纤维的机械戒断阈值均无显著变化。与假泳组（1076 +/- 102.4 s）相比，强迫游泳应激组在最后一次应激期后2天（1330.1 +/- 62.8 s）对福尔马林皮下注射的有害行为显著增强
In the present study we examined whether the descending facilitation from the rostral ventromedial medulla (RVM) is required for the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress. Rats were subjected to forced or sham swim stress for 3 days. Withdrawal latency to noxious thermal stimuli and mechanical withdrawal threshold to von Frey filaments did not change significantly in both groups at 24h after the last stress session. The forced swim stress showed significantly enhanced nocifensive behavior to the subcutaneous administration of formalin at 2 days after the last stress session (1330.1 +/- 62.8 s), compared to the sham swim (1076 +/- 102.4 s, p