Acute Effect of Alginate-Based Preload on Satiety Feelings, Energy Intake, and Gastric Emptying Rate in Healthy Subjects
Acute Effect of Alginate-Based Preload on Satiety Feelings, Energy Intake, and Gastric Emptying Rate in Healthy Subjects
复制标题
DOI：
10.1038/oby.2011.232
复制
发表时间：
2012-09-01
期刊：
影响因子：
6.9
通讯作者：
Astrup, Arne
中科院分区：
文献类型：
--
作者：
Jensen, Morten Georg;Kristensen, Mette;Astrup, Arne
从褐藻中提取的海藻酸钠等粘性膳食纤维由于其通过抑制能量摄入和增加饱腹感而在能量调节中的潜在作用，最近受到了广泛关注。本研究的目的是通过对乙酰氨基酚方法，研究两种不同体积的藻酸盐预负荷对正常体重受试者餐后饱腹感、能量摄入和胃排空率（格尔）的影响。在一项四向安慰剂对照、双盲、交叉试验中，20名受试者（年龄：25.9 +/- 3.4岁; BMI：23.5 +/- 1.7 kg/m2）被随机分配接受3%的前负荷浓度或低容量Og藻酸盐）或高体积（HV; 500 ml中15. Og藻酸盐）基于藻酸盐的饮料，或等体积安慰剂饮料。在固定早餐前30 mm摄入预负荷，并在随意午餐前再次摄入。在接下来的午餐中，LV-藻酸盐预负荷的消耗诱导了比安慰剂饮料显著更低的能量摄入（8.0%）（P = 0.040），而在饱腹感或扑热息痛浓度方面没有差异。与安慰剂相比，HV藻酸盐显著增加了饱腹感（P = 0.038），减少了饥饿感（P = 0.042）和预期摄食量（P = 0.027），并降低了对乙酰氨基酚浓度的曲线下面积（iAUC）（P = 0.05）。然而，HV藻酸盐仅观察到能量摄入减少5.5%（P = 0.20）。虽然它们有些矛盾，但我们的研究结果表明，藻酸盐的消耗确实会影响饱腹感和能量摄入。然而，在推断这种纤维在短期能量调节中可能起作用之前，需要进一步研究藻酸盐的施用量。
Viscous dietary fibers such as sodium alginate extracted from brown seaweed have received much attention lately for their potential role in energy regulation through the inhibition of energy intake and increase of satiety feelings. The aim of our study was to investigate the effect on postprandial satiety feelings, energy intake, and gastric emptying rate (GER), by the paracetamol method, of two different volumes of an alginate-based preload in normal-weight subjects. In a four-way placebo-controlled, double-blind, crossover trial, 20 subjects (age: 25.9 +/- 3.4 years; BMI: 23.5 +/- 1.7 kg/m(2)) were randomly assigned to receive a 3% preload concentration of either low volume (LV; 9.9g alginate in 330 ml) or high volume (HV; 15.0g alginate in 500 ml) alginate-based beverage, or an iso-volume placebo beverage. The preloads were ingested 30 mm before a fixed breakfast and again before an ad libitum lunch. Consumption of LV-alginate preload induced a significantly lower (8.0%) energy intake than the placebo beverage (P = 0.040) at the following lunch meal, without differences in satiety feelings or paracetamol concentrations. The HV alginate significantly increased satiety feelings (P = 0.038), reduced hunger (P = 0.042) and the feeling of prospective food consumption (P = 0.027), and reduced area under the curve (iAUC) paracetamol concentrations compared to the placebo (P = 0.05). However, only a 5.5% reduction in energy intake was observed for HV alginate (P = 0.20). Although they are somewhat contradictory, our results suggest that alginate consumption does affect satiety feelings and energy intake. However, further investigation on the volume of alginate administered is needed before inferring that this fiber has a possible role in short-term energy regulation.