Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides
Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides
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DOI：
10.1016/j.brainresrev.2007.03.006
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发表时间：
2007-08-01
影响因子：
--
通讯作者：
Antonelli, Tiziana
中科院分区：
文献类型：
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作者：
Ferraro, Luca;Tomasini, Maria C.;Antonelli, Tiziana
十三肽神经降压素（NT）在哺乳动物脑中作为主要神经递质或经典神经递质的神经调质起作用。形态和功能的体外和体内研究表明，在边缘和纹状体脑区的NT和多巴胺之间存在密切的相互作用。此外，生物化学和神经化学证据表明，在这些脑区的NT也发挥了至关重要的作用，在氨基酸能信号的调节。这表明，在延髓核的调节prejunctional多巴胺能传输诱导NT可能主要是由于间接机制（S）涉及通过氨基酸能神经元系统的调解与谷氨酸释放增加，然后增加GABA释放在延髓核，而不是直接作用的肽对多巴胺能末梢。NT在控制多巴胺、谷氨酸和GABA释放模式中的神经化学作用概况在很大程度上不同于背侧纹状体中的肽。神经调节NT机制的腹侧纹状体苍白球GABA通路的调节进行了讨论，并强调其与精神分裂症的相关性。(c)2007 Elsevier B.V.保留所有权利。
The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters. Morphological and functional in vitro and in vivo studies have demonstrated the existence of close interactions between NT and dopamine both in limbic and in striatal brain regions. Additionally, biochemical and neurochemical evidence indicates that in these brain regions NT plays also a crucial role in the regulation of the aminoacidergic signalling. It is suggested that in the nucleus accumbens the regulation of prejunctional dopaminergic transmission induced by NT may be primarily due to indirect mechanism(s) involving mediation via the aminoacidergic neuronal systems with increased glutamate release followed by increased GABA release in the nucleus accumbens rather than a direct action of the peptide on accumbens dopaminergic terminals. The neurochemical profile of action of NT in the control of the pattern of dopamine, glutamate and GABA release in the nucleus accumbens differs to a substantial degree from that shown by the peptide in the dorsal striatum. The neuromodulatory NT mechanisms in the regulation of the ventral striato-pallidal GABA pathways are discussed and their relevance for schizophrenia is underlined. (c) 2007 Elsevier B.V. All rights reserved.