Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".
Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".
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对“DNA 损伤是测序错误的普遍原因，直接混淆变异识别”的评论。
DOI：
10.1126/science.aas9824
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Getz,Gad
中科院分区：
文献类型：
--
作者：
Stewart,Chip;Leshchiner,Ignaty;Hess,Julian;Getz,Gad
Chenet al. (Reports, 17 February 2017, p. 752) highlight an important problem of sequencing artifacts caused by DNA damage at the time of sample processing. However, their manuscript contains several errors that led the authors to incorrect conclusions. Moreover, the same sequencing artifacts were previously described and mitigated in The Cancer Genome Atlas and other published sequencing projects.
