Cortical integration of higher-order thalamic inputs is lineage-dependent
Cortical integration of higher-order thalamic inputs is lineage-dependent
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DOI：
10.1101/2022.03.28.486015
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Matthew J. Buchan;Kashif Mahfooz;Joram J. van Rheede;Gemma Gothard;Sophie V. Avery;T. Ellender;S. Newey;C. Akerman
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文献类型：
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作者：
Matthew J. Buchan;Kashif Mahfooz;Joram J. van Rheede;Gemma Gothard;Sophie V. Avery;T. Ellender;S. Newey;C. Akerman
初级感觉皮层接收和整合来自丘脑一级和高级核团的输入。一阶输入传达来自外围的感觉信息，并表现出简单的响应特性，而高阶输入表现出更复杂的响应特性，提供上下文反馈，并可以调制一阶输入。在这里，我们表明，皮质神经元整合这些丘脑输入的方式，反映了皮质神经元来源的祖细胞。在小鼠初级体感皮层的第4层内，来自顶端中间祖细胞的兴奋性神经元表现出多须响应特性，并以与其树突形态一致的方式接收高阶丘脑输入。这些特性取决于转录因子Lhx2的表达水平，当其增加时，废除顶端中间祖细胞衍生的神经元的高阶特性，并破坏感觉诱发的可塑性的诱导。这些数据揭示了一个谱系依赖的机制，建立了皮层内的高阶丘脑输入的整合和功能的贡献。
Primary sensory cortex receives and integrates inputs from first-order and higher-order thalamic nuclei. First-order inputs convey sensory information from the periphery and exhibit simple response properties, whereas higher-order inputs exhibit more complex response properties, provide contextual feedback, and can modulate first-order inputs. Here we show that the way in which cortical neurons integrate these thalamic inputs, reflects the progenitor cell from which the cortical neurons derive. Within layer 4 of mouse primary somatosensory cortex, excitatory neurons that derive from apical intermediate progenitors exhibit multi-whisker response properties and receive higher-order thalamic input, in a manner consistent with their dendritic morphology. These properties depend upon the expression levels of the transcription factor Lhx2, which when increased, abolishes the higher-order properties of apical intermediate progenitor-derived neurons, and disrupts the induction of sensory-evoked plasticity. These data reveal a lineage-dependent mechanism that establishes the integration and functional contribution of higher-order thalamic inputs within cortex.