A sight on the current nanoparticle-based gene delivery vectors.
A sight on the current nanoparticle-based gene delivery vectors.
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DOI：
10.1186/1556-276x-9-252
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发表时间：
2014
影响因子：
--
通讯作者：
Khosroushahi AY
中科院分区：
文献类型：
--
作者：
Dizaj SM;Jafari S;Khosroushahi AY
目前，基因治疗被认为是治疗人类遗传性疾病和获得性疾病的最有前途的策略之一。设计具有高转染效率和低细胞毒性的高效基因递送载体被认为是将靶基因递送到特定组织或细胞的主要挑战。在此基础上，对具有克服生理障碍能力的非病毒基因载体的研究日益增多。在非病毒载体中，纳米颗粒显示出关于基因递送的显著特性，例如靶向特定组织或细胞的能力，保护靶基因免受核酸酶降解，改善DNA稳定性，以及增加转化效率或安全性。这篇评论试图代表目前的纳米粒子的基础上，其脂质，聚合物，混合物，和无机性能。其中，杂交体作为高效载体，在材料（合成或天然）、设计和体外/体内转化效率方面用于基因递送。
Nowadays, gene delivery for therapeutic objects is considered one of the most promising strategies to cure both the genetic and acquired diseases of human. The design of efficient gene delivery vectors possessing the high transfection efficiencies and low cytotoxicity is considered the major challenge for delivering a target gene to specific tissues or cells. On this base, the investigations on non-viral gene vectors with the ability to overcome physiological barriers are increasing. Among the non-viral vectors, nanoparticles showed remarkable properties regarding gene delivery such as the ability to target the specific tissue or cells, protect target gene against nuclease degradation, improve DNA stability, and increase the transformation efficiency or safety. This review attempts to represent a current nanoparticle based on its lipid, polymer, hybrid, and inorganic properties. Among them, hybrids, as efficient vectors, are utilized in gene delivery in terms of materials (synthetic or natural), design, and in vitro/in vivo transformation efficiency.