Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
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DOI：
10.1007/s11427-020-1643-8
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发表时间：
2020-02-09
影响因子：
9.1
通讯作者：
Liu, Lei
中科院分区：
文献类型：
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作者：
Liu, Yingxia;Yang, Yang;Liu, Lei
2019-nCoV感染于2019年12月在湖北省武汉市爆发，并迅速蔓延到中国的许多省份以及其他国家。在这里，我们报告了中国深圳2019-nCoV感染患者的流行病学，临床，实验室和放射学特征，以及预测疾病严重程度的潜在生物标志物。所有12例2019-nCoV感染患者均发生肺炎，其中一半发生急性呼吸窘迫综合征（ARDS）。最常见的实验室检查异常为低白蛋白血症、淋巴细胞减少、淋巴细胞（LYM）和中性粒细胞（NEU）百分比降低、C反应蛋白（CRP）和乳酸脱氢酶（LDH）升高以及CD 8计数降低。从患者呼吸道检测到的2019-nCoV病毒载量与肺部疾病严重程度呈正相关。ALB、LYM、LYM（%）、LDH、NEU（%）、CRP与急性肺损伤高度相关。年龄、病毒载量、肺损伤评分、血生化指标、白蛋白（ALB）、CRP、LDH、LYM（%）、LYM和NEU（%）可能是疾病严重程度的预测因子。此外，2019-nCoV感染患者血浆样本中的血管紧张素II水平显著升高，并与病毒载量和肺损伤呈线性相关。我们的研究结果表明，许多潜在的诊断生物标志物和血管紧张素受体阻滞剂（ARB）药物可用于2019-nCoV感染的潜在再利用治疗。
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.