Determinants of High-Risk Human Papillomavirus Seroprevalence and DNA Prevalence in Mid-Adult Women.
Determinants of High-Risk Human Papillomavirus Seroprevalence and DNA Prevalence in Mid-Adult Women.
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DOI：
10.1097/olq.0000000000000409
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发表时间：
2016-03
影响因子：
3.1
通讯作者：
Winer RL
中科院分区：
文献类型：
--
作者：
Sadate-Ngatchou P;Carter JJ;Hawes SE;Feng Q;Lasof T;Stern JE;Fu TC;Galloway DA;Koutsky LA;Winer RL
The epidemiology of hrHPV infections in mid-adult women is not well understood. We conducted a cross-sectional analysis of 379 30–50 year old females. Vaginal samples were tested for type-specific HPV DNA by PCR. Sera were tested for type-specific HPV antibodies by Luminex-based assay. Assays included 13 hrHPV types (16/18/31/33/35/39/45/51/52/56/58/59/68). Self-reported health and sexual history were ascertained. Risk factors for seropositivity and DNA positivity to hrHPV were assessed in separate Poisson regression models. The mean (standard deviation) age of participants was 38.7 (6.1) years, and the median lifetime number of male sex partners was 7. About two-thirds (68.1%) were seropositive for any hrHPV, 15.0% were DNA positive, and 70.7% were seropositive or DNA positive. In multivariate analyses, women who were married/living with a partner were less likely to be seropositive than single/separated women (adjusted prevalence ratio [aPR]=0.86, 95%CI:0.75–0.98). Compared to never hormonal contraceptive users, current (aPR=1.53,95%CI:1.01–2.29) or former (aPR=1.64,95%CI:1.10–2.45) users were more likely to be seropositive. Women with a lifetime number of sex partners ≥12 were more likely to be seropositive compared to those with 0–4 partners (aPR=1.29,95%CI:1.06–1.56). Similar associations were seen with DNA positivity. In addition, there was a positive association between current smoking and hrHPV DNA (aPR versus never smokers=2.51, 95%CI:1.40–4.49). 71% of mid-adult women had evidence of current or prior hrHPV infection. Measures of probable increased exposure to HPV infection were associated with both seropositivity and DNA positivity to hrHPV, whereas current smoking was positively associated with hrHPV DNA only.
