Molecular mechanisms of gene regulation during Drosophila spermatogenesis.
Molecular mechanisms of gene regulation during Drosophila spermatogenesis.
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DOI：
10.1530/rep-09-0083
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发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
H. White-Cooper
中科院分区：
文献类型：
--
作者：
H. White-Cooper
将精子从形态平凡的细胞分化为高度专业化的自由生活、能动的细胞，需要大量基因产物的协同作用。这些产物的表达必须在发育背景下进行调节，以确保正常的细胞分化。许多精子发生所必需的基因没有在动物体内的其他地方使用，或者在其他地方表达，但使用了不同的转录调节模块。因此，精子发生是阐明组织特异性基因表达原理的一个很好的系统，而且本身就很有趣。在这里，我讨论了果蝇精子发生过程中基因表达的调节，重点是雄性生殖系中睾丸特异基因表达的潜在过程。
The differentiation of sperm from morphologically unremarkable cells into highly specialised free-living, motile cells requires the co-ordinated action of a very large number of gene products. The expression of these products must be regulated in a developmental context to ensure normal cellular differentiation. Many genes essential for spermatogenesis are not used elsewhere in the animal, or are expressed elsewhere, but using a different transcription regulation module. Spermatogenesis is thus a good system for elucidating the principles of tissue-specific gene expression, as well as being interesting in its own right. Here, I discuss the regulation of gene expression during spermatogenesis in Drosophila, focussing on the processes underlying the expression of testis-specific genes in the male germline.