A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii
A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii
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雷公藤根中一种新的去甲基松香烷二萜类化合物
DOI：
10.1080/14786419.2019.1610749
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发表时间：
2019-06-22
影响因子：
2.2
通讯作者：
Zhang, Zhi-Qiang
中科院分区：
文献类型：
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作者：
Li, Peng;Shen, Shao-Xin;Zhang, Zhi-Qiang
从雷公藤（Tripterygium wilfordii Hook）的根中分得一个新的去甲基松香烷型二萜化合物Triptotin K（3）和三个已知化合物木栓酮（1）、canophyllal（2）和雷公藤内酯醇（4）。F.采用硅胶柱和制备型高效液相色谱法。通过大量的NMR数据和质谱分析确定了它们的结构。曲普汀K对KB、KBv 200、HepG 2和MCF-7/ADM细胞株具有细胞毒活性，IC 50值分别为29.88、36.50、39.55和41.38 μM。图形摘要
Abstract A new demethyl abietane diterpenoid, Triptotin K (3) together with three known compounds, friedelin (1), canophyllal (2), and triptonoterpene (4) were isolated from the roots of Tripterygium wilfordii Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC50 values of 29.88, 36.50, 39.55, and 41.38 μM, respectively. Graphical Abstract