Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report
Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report
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单倍相合干细胞移植供体发展为淋巴瘤：病例报告。
DOI：
10.3892/mco.2017.1414
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发表时间：
2017-11-01
影响因子：
1.2
通讯作者：
Zhou, Fang
中科院分区：
文献类型：
--
作者：
Xie, Linnna;Zhou, Fang
移植后淋巴细胞增生性疾病（PTLD）是造血干细胞移植（HSCT）后的严重并发症。大多数病例发生在移植后的第一年，并与eb病毒（EBV）的重新激活有关；ebv诱导的淋巴细胞增殖通常包括供体来源的B细胞。我们在此描述了一位28岁的女性患者，她在接受父亲的单倍体造血干细胞移植6个月后患上ebv阴性PTLD，即弥漫性大b细胞淋巴瘤（DLBCL）。用XY荧光原位杂交进行的嵌合分析显示来自供体的b细胞PTLD。不幸的是，供者在捐献祖细胞380天后也发生了DLBCL，尽管他在捐献时血液学正常。本病例表明，从供体传播的疾病可能是PTLD的一个可能原因。
Post-transplantation lymphoproliferative disease (PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). The majority of the cases develop during the first year after the transplantation and are associated with reactivation of the Epstein-Barr virus (EBV); the EBV-induced lymphoproliferation usually includes donor-derived B cells. We herein describe the case of a 28-year-old female patient who developed EBV-negative PTLD, namely diffuse large B-cell lymphoma (DLBCL), 6 months after receiving a haploidentical HSCT from her father. Chimerism analysis performed with XY fluorescence in situ hybridization revealed a B-cell PTLD originating from the donor. Unfortunately, the donor also developed DLBCL 380 days after donating progenitor cells, although he was hematologically normal at the time of donation. The present case demonstrated that disease transmitted from the donor may be a possible cause of PTLD.