The effects of hydroxychloroquine on endothelial dysfunction
The effects of hydroxychloroquine on endothelial dysfunction
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DOI：
10.1016/j.preghy.2016.09.001
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发表时间：
2016-10-01
影响因子：
2.2
通讯作者：
Wallace, Euan M.
中科院分区：
文献类型：
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作者：
Rahman, Rahana;Murthi, Padma;Wallace, Euan M.
羟氯喹是一种抗疟疾药物，由于其抗炎和免疫调节作用，被广泛用于治疗自身免疫性疾病。在系统性红斑狼疮的模型中，羟氯喹已被证明具有保护内皮的作用。在这项研究中，我们的目的是调查是否羟氯喹是在TNF-α和先兆子痫血清诱导功能障碍的体外模型内皮保护。我们发现，羟氯喹显着减少生产的TNF-α和先兆子痫血清诱导内皮素-1（ET-1）。羟氯喹还显著减轻TNF-α诱导的血管生成损伤。这些发现支持进一步评估羟氯喹作为辅助治疗先兆子痫。(C)2016年国际妊娠高血压研究学会。Elsevier B. V.出版，保留所有权利。
Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-alpha and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TINF-alpha and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-alpha induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia. (C) 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.