Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx.
Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx.
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DOI：
10.1186/1749-799x-5-37
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发表时间：
2010-06-15
影响因子：
2.6
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Zhang C
骨形成是一个复杂的发育过程，涉及到间充质干细胞向成骨细胞的分化。成骨细胞的分化是通过不同转录因子和信号蛋白调控的多步分子途径进行的。OSX(也称为SP7)是迄今为止发现的唯一一种成骨细胞特异性转录因子，是成骨细胞分化和骨形成所必需的。OSX基因敲除小鼠完全缺乏骨骼，软骨正常。这为骨形成的整个研究领域打开了一扇新的窗口。OSX抑制Wnt途径信号转导，这可能是OSX抑制成骨细胞增殖的机制之一。这些报道表明，OSX是控制成骨细胞谱系定位和随后的成骨细胞增殖和分化的主要基因。本文就OSX转录调控骨形成分子机制的最新研究进展作一综述。
Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling proteins. Osx (also known as Sp7) is the only osteoblast-specific transcriptional factor identified so far which is required for osteoblast differentiation and bone formation. Osx knock-out mice lack bone completely and cartilage is normal. This opens a new window to the whole research field of bone formation. Osx inhibits Wnt pathway signaling, a possible mechanism for Osx to inhibit osteoblast proliferation. These reports demonstrate that Osx is the master gene that controls osteoblast lineage commitment and the subsequent osteoblast proliferation and differentiation. This review is to highlight recent progress in understanding the molecular mechanisms of transcriptional regulation of bone formation by Osx.