ELECTROLYTIC LESIONS OF THE AMYGDALA BLOCK ACQUISITION AND EXPRESSION OF FEAR-POTENTIATED STARTLE EVEN WITH EXTENSIVE TRAINING BUT DO NOT PREVENT REACQUISITION
ELECTROLYTIC LESIONS OF THE AMYGDALA BLOCK ACQUISITION AND EXPRESSION OF FEAR-POTENTIATED STARTLE EVEN WITH EXTENSIVE TRAINING BUT DO NOT PREVENT REACQUISITION
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DOI：
10.1037/0735-7044.107.4.580
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发表时间：
1993-08-01
影响因子：
1.9
通讯作者：
DAVIS, M
中科院分区：
文献类型：
--
作者：
KIM, M;DAVIS, M
杏仁核的损伤已经被证明可以阻止恐惧增强惊吓的表达（在先前与休克配对的线索存在的情况下，声音惊吓增加）。在本研究中，广泛的训练后给予杏仁核中央核的双侧病变完全阻断恐惧增强惊吓的表达，但并没有阻止再捕获。相比之下，当在任何训练之前进行损伤时，即使经过大量训练，损伤大鼠也没有表现出增强的惊吓。因此，杏仁核的中央核通常似乎是需要的初步收购和表达的增强惊吓，无论学习的程度。然而，在没有中央核团的情况下，强化惊吓的重新获得也可能发生，这意味着在某些情况下，存在一个次级脑系统，可以补偿杏仁核中央核团的损失。
Lesions of the amygdala have been shown to block the expression of fear-potentiated startle (increased acoustic startle in the presence of a cue previously paired with shock). In the present study, bilateral lesions of the central nucleus of the amygdala given after extensive training totally blocked the expression of fear-potentiated startle but did not prevent reacquisition. In contrast, when the lesions were made before any training, the lesioned rats did not show potentiated startle even with extensive training. Thus, the central nucleus of the amygdala normally seems to be required for the initial acquisition and expression of potentiated startle regardless of the degree of learning. However, reacquisition of potentiated startle can occur without the central nucleus, which implies the presence of a secondary brain system that can compensate for the loss of the central nucleus of the amygdala under some circumstances.