Transthyretin: the servant of many masters.
Transthyretin: the servant of many masters.
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DOI：
10.1007/s00018-009-0109-0
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Reixach N
中科院分区：
文献类型：
--
作者：
Buxbaum JN;Reixach N
甲状腺素运载蛋白（TTR）（以前称为甲状腺素结合前白蛋白）是一种进化上保守的血清和脑脊液蛋白，可转运全视黄醇结合蛋白和甲状腺素。其血清浓度已被广泛用于评估临床营养状况。众所周知，野生型甲状腺素运载蛋白和大约100种不同的突变体引起多种形式的系统性淀粉样蛋白沉积。在脑Aβ沉积的转基因动物模型中，TTR可以抑制阿尔茨海默病的表型，这一点已被怀疑并在最近得到证实。因此，虽然TTR是全身性淀粉样蛋白前体，但在大脑中似乎具有抗淀粉样蛋白生成作用。TTR在其他器官中被发现是局部合成或运输的结果，这表明它可能具有其他尚未发现的功能。可能的是，其结合许多种类的化合物的能力允许其充当具有潜在病理效应的分子的内源性解毒剂。
Transthyretin (TTR) (formerly, thyroxine binding prealbumin) is an evolutionarily conserved serum and cerebrospinal fluid protein that transports holo-retinol-binding protein and thyroxine. Its serum concentration has been widely used to assess clinical nutritional status. It is also well known that wild-type transthyretin and approximately 100 different mutants give rise to a variety of forms of systemic amyloid deposition. It has been suspected and recently established that TTR can suppress the Alzheimer’s disease phenotype in transgenic animal models of cerebral Aβ deposition. Thus, while TTR is a systemic amyloid precursor, in the brain it seems to have an anti-amyloidogenic effect. TTR is found in other organs as a result of local synthesis or transport, suggesting that it may have other, as yet undiscovered, functions. It is possible that its capacity to bind many classes of compounds allows it to serve as an endogenous detoxifier of molecules with potential pathologic effects.