Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment.
Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment.
复制标题
乳酸引起的恐慌期间脑代谢的变化：加巴喷丁治疗的影响。
DOI：
10.1002/da.1076
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Dager,SR
中科院分区：
文献类型：
--
作者：
Layton,ME;Friedman,SD;Dager,SR
6例惊恐障碍受试者在研究开始时接受乳酸钠输注联合磁共振波谱成像（MRSI），当时症状活跃，临床改善，同时接受加巴喷丁治疗。MRSI被用来连续测量局部脑乳酸水平，从一个轴向截面在基线水平的侧脑室，在乳酸输液和乳酸输液后。加巴喷丁治疗似乎可有效阻断乳酸盐诱导的惊恐反应，但在所有受试者中，未改变对乳酸盐输注的异常脑乳酸盐反应的幅度或时程。此外，2例受试者在接受双盲安慰剂治疗后临床改善时进行了再输注，并表现出一致的异常脑乳酸反应模式。 抑郁和焦虑14：251-254，2001。© 2001 Wiley利斯公司
Six subjects with panic disorder underwent sodium lactate infusions in conjunction with magnetic resonance spectroscopic imaging (MRSI) at study entrance when actively symptomatic and after clinical improvement while under treatment with gabapentin. MRSI was used to serially measure regional brain lactate levels from an axial section at the level of the lateral ventricles at baseline, during lactate infusion and postlactate infusion. Gabapentin treatment appeared to be effective in blocking a lactate‐induced panic response but did not alter the magnitude or time course of an abnormal brain lactate response to lactate infusion in all subjects. Additionally, two subjects were reinfused while clinically improved on double‐blind placebo and demonstrated a consistent pattern of abnormal brain lactate response. Depression and Anxiety 14:251–254, 2001. © 2001 Wiley‐Liss, Inc.