Classification of chronic myelocytic leukemia in children
Classification of chronic myelocytic leukemia in children
复制标题
儿童慢性粒细胞白血病的分类
DOI：
10.1002/1097-0142(197409)34:3
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发表时间：
1974
期刊：
影响因子：
6.2
通讯作者：
W. Johnson
中科院分区：
文献类型：
--
作者：
Kirby L. Smith;W. Johnson
本研究旨在确定儿童和青少年慢性粒细胞白血病的分类标准。从1963年4月到1971年7月，18名患者可用于研究。对临床、实验室和组织病理学特征的评价显示了三个不同的亚组：成人、青少年和家族性慢性粒细胞白血病。在这一区别中最有价值的参数是白色血细胞计数水平、是否存在血小板减少症或血小板增多症、骨髓髓细胞与红细胞比例以及脾脏中是否存在明确的马氏小体。1例急性淋巴细胞白血病缓解期患者表现出一些独特的特征，可能代表第四种形式的慢性粒细胞白血病，由既往化疗或放疗引起。使用化疗并没有显著延长我们患者的生存期。两例家族性慢性粒细胞白血病患者在脾切除术后存活9年。
The present study was undertaken to define criteria for classification of chronic myelocytic leukemia in children and adolescents. From April, 1963 through July, 1971, 18 patients were available for study. Evaluation of the clinical, laboratory, and histopathologic features demonstrates three distinct subgroups: adult, juvenile, and familial chronic myelocytic leukemia. Parameters of most value in this distinction are the level of the white blood cell count, presence of thrombocytopenia or thrombocytosis, the bone marrow myeloid to erythroid ratio, and the presence or absence of well‐defined malpighian corpuscles in the spleen. One patient with acute lymphocytic leukemia in remission manifested some unique features and may represent a fourth form of chronic myelocytic leukemia, resulting from previous chemotherapy or irradiation. The use of chemotherapy has not significantly prolonged survival in our patients. Two patients with familial chronic myelocytic leukemia are surviving in remission 9 years following splenectomy.