QUANTITATIVE EVIDENCE FOR SELECTIVE DENDRITIC GROWTH IN NORMAL HUMAN AGING BUT NOT IN SENILE DEMENTIA
QUANTITATIVE EVIDENCE FOR SELECTIVE DENDRITIC GROWTH IN NORMAL HUMAN AGING BUT NOT IN SENILE DEMENTIA
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DOI：
10.1016/0006-8993(81)90436-4
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
COLEMAN, PD
中科院分区：
文献类型：
--
作者：
BUELL, SJ;COLEMAN, PD
在尸检时从人脑中采集海马旁回样本，分为 3 组：成人（n = 5，平均年龄 51.2 岁）、正常年龄（n = 5，平均年龄 79.6 岁）和老年痴呆（SD）（n = 5，平均年龄 76.0 岁）。正常老年人或老年痴呆症的分类是基于行为和神经病理学标准。对组织进行高尔基-考克斯染色、甲酚紫染色、苏木精和曙红染色以及博迪安银染色。在所有情况下都可以看到萎缩的树突树和正常的树突树。使用计算机显微镜系统对第二层锥体神经元的树突进行量化。定量数据表明，正常老年人比成年人或 SD 个体具有更长、更多分支的树突。 SD 个体比成年人具有更短、更少分支的树突的轻微趋势。树突树顶端部分的组间差异大于基部部分的差异。这些差异很大程度上是由末端树突片段的延长和分枝（顶端树突）或仅延长（基部树突）造成的。这些数据提出了一个模型，其中衰老的皮层既包含退化的、垂死的神经元，也包含存活的、生长的神经元。在正常衰老过程中，后者占主导地位。这是成人大脑可塑性的第一次证明。
Parahippocampal gyrus was sampled from human brains at autopsy to form 3 groups: adult (n = 5, mean age 51.2 yr), normal aged (n = 5, mean age 79.6 yr) and senile dementia (SD) (n = 5, mean age 76.0 yr). Classification as normal aged or senile demented was based on both behavioral and neuropathological criteria. Tissue was processed for Golgi-Cox, cresyl violet, hematoxylin and eosin and Bodian silver stains. Both atrophied and normal dendritic trees were seen in all cases. Dendrites of layer II pyramidal neurons were quantified with a computer-microscope system. Quantitative data showed that normal aged individuals had longer and more branched dendrites than either adult or SD individuals. There was a slight tendency for SD individuals to have shorter, less-branched dendrites than adults. Differences among groups were greater in apical than in basal portions of the dendritic tree. These differences were largely accounted for by the lengthening and branching (apical dendrites) or lengthening only (basal dendrites) of terminal dendritic segments. These data suggest a model in which aging cortex contains both regressing, dying neurons and surviving, growing neurons. In normal aging it is the latter group that predominates. This is the 1st demonstration of plasticity in the adult human brain.