Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury
Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury
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DOI：
10.1016/j.atherosclerosis.2014.08.044
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发表时间：
2014-11-01
期刊：
影响因子：
5.3
通讯作者：
Daida, Hiroyuki
中科院分区：
文献类型：
--
作者：
Ogita, Manabu;Miyauchi, Katsumi;Daida, Hiroyuki
目的：血管介入治疗后的呼吸仍然是一个主要的临床问题。在人类和动物研究中，循环LR11已被证明是内膜平滑肌细胞（SMC）增殖的新标志物。本研究旨在阐明冠状动脉支架植入术后稳定型心绞痛患者循环LR11的临床意义。方法和结果：我们首先研究了小鼠动脉损伤后28天循环sLR11水平，然后评估了冠状动脉支架植入术后循环sLR11水平的时间依赖性变化。在术后第14天（POD），小鼠sLR11水平迅速增加至对照值的4.0倍，而没有袖带放置，并且该水平逐渐下降至对照值的3.1倍，直到POD 28。在对102名接受经皮冠状动脉介入治疗的连续稳定型心绞痛患者进行的临床研究中，测量了冠状动脉支架植入术前和植入术后14、60和240天的循环可溶性LR 11水平。循环sLR11水平显着增加14和60天后的程序和正相关的血管造影晚期损失index.Conclusions：我们的研究表明，循环sLR11水平可能是一个潜在的标志物血管造影晚期损失的患者冠状动脉支架植入术后。sLR 11作为内膜SMC的新标志物，其作用机制有待进一步研究。(C)由Elsevier爱尔兰Ltd.出版
Objective: Restenosis after vascular intervention remains a major clinical problem. Circulating LR11 has been shown a novel marker of intimal smooth muscle cell (SMC) proliferation in human and animal studies. The present study was performed to clarify the clinical significance of circulating LR11 in patients with stable angina pectoris after coronary stenting.Methods and results: We firstly investigated the circulating sLR11 levels for 28 days after arterial injury in mice, and then assessed time-dependent change in circulating sLR11 level after coronary stenting in a clinical study. Mouse sLR11 levels rapidly increased to 4.0-fold of the control value without cuff placement at postoperative day (POD) 14, and the levels gradually declined to 3.1-fold of the control value until POD 28 in mice. The circulating soluble LR11 levels were measured (before and at 14, 60 and 240 days after coronary stenting in a clinical study of 102 consecutive patients with stable angina pectoris who were treated with percutaneous coronary intervention. Circulating sLR11 levels were significantly increased on days 14 and 60 after the procedure and positively associated with the angiographic late loss index.Conclusions: Our study suggested that circulating sLR11 levels may be a potential marker for angiographic late loss in patients after coronary stenting. Further mechanistic studies are expected to know the clinical significance of sLR11 as a novel marker for intimal SMC. (C) 2014 Published by Elsevier Ireland Ltd.