Fourier X-ray Scattering Radiography Yields Bone Structural Information
Fourier X-ray Scattering Radiography Yields Bone Structural Information
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DOI：
10.1148/radiol.2521081903
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发表时间：
2009-06-01
期刊：
影响因子：
19.7
通讯作者：
Rapacchi, Stanislas
中科院分区：
文献类型：
--
作者：
Wen, Han;Bennett, Eric E.;Rapacchi, Stanislas
目的：为了表征某些方面的微观结构的皮质骨和骨小梁通过使用傅立叶X射线散射imaging.Materials和方法：美国国立卫生研究院动物护理和使用委员会批准的协议被用来检查离体后肢的大鼠和脚趾的猪。傅立叶X射线散射成像技术涉及使用网格掩模来调制锥形束和傅立叶光谱滤波器来隔离谐波图像。该技术产生衰减，散射和相位对比（PC）的图像从一个单一的曝光。在大鼠胫骨皮质骨，散射信号从两个正交的网格方向进行了比较，通过使用Wilcoxon符号秩检验。结果：在骨皮质，当网格平行于骨膜表面时，散射信号明显高于均匀衰减的骨小梁区（P < 10（-15）），当网格平行于骨膜表面时，散射信号高于均匀衰减的骨小梁区（P <0.05）。与皮质骨相比，松质骨在散射（P < 10（-34））和PC（P < 10（-27））图像上呈现高度不均匀性。结论：密质骨中矿化胶原纤维的有序排列反映在该骨的各向异性散射信号中。在松质骨中，矿化基质的孔隙率解释了散射和PC图像上看到的颗粒图案。(C)RSNA，2009年
Purpose: To characterize certain aspects of the microscopic structures of cortical and trabecular bone by using Fourier x-ray scattering imaging.Materials and Methods: Protocols approved by the National Institutes of Health Animal Care and Use Committee were used to examine ex vivo the hind limb of a rat and the toe of a pig. The Fourier x-ray scattering imaging technique involves the use of a grid mask to modulate the cone beam and Fourier spectral filters to isolate the harmonic images. The technique yields attenuation, scattering, and phase-contrast (PC) images from a single exposure. In the rat tibia cortical bone, the scattering signals from two orthogonal grid orientations were compared by using Wilcoxon signed rank tests. In the pig toe, the heterogeneity of scattering and PC signals was compared between trabecular and compact bone regions of uniform attenuation by using F tests.Results: In cortical bone, the scattering signal was significantly higher (P < 10(-15)) when the grid was parallel to the periosteal surface. Trabecular bone, as compared with cortical bone, appeared highly heterogeneous on the scattering (P < 10(-34)) and PC (P < 10(-27)) images.Conclusion: The ordered alignment of the mineralized collagen fibrils in compact bone was reflected in the anisotropic scattering signal in this bone. In trabecular bone, the porosity of the mineralized matrix accounted for the granular pattern seen on the scattering and PC images. (C) RSNA, 2009