Invertebrate troponin: Insights into the evolution and regulation of striated muscle contraction
Invertebrate troponin: Insights into the evolution and regulation of striated muscle contraction
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DOI：
10.1016/j.abb.2019.03.013
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发表时间：
2019-05-15
影响因子：
3.9
通讯作者：
Jin, Jian-Ping
中科院分区：
文献类型：
--
作者：
Cao, Tianxin;Thongam, Urvashi;Jin, Jian-Ping
肌钙蛋白复合体在调节横纹肌的收缩和松弛方面起着核心作用。在肌钙蛋白的三个亚基中，钙受体亚基TNC属于钙信号蛋白钙调蛋白家族，而抑制亚基TnI和原肌球蛋白结合/细丝锚定亚基TnT是横纹肌特异性调节蛋白。TnI和TnT很早就出现在双侧对称性无脊椎动物身上，并在肌肉进化的5-7亿年中共同进化。了解TnI和TnT在无脊椎动物和脊椎动物中的结构差异和保守性，为肌钙蛋白的结构-功能关系以及TnI和TnT的肌肉类型亚型提供了新的见解。基于过去十年来多种物种基因组数据库的显著增长，本文对无脊椎动物肌钙蛋白亚基的一级结构特征与脊椎动物的肌钙蛋白亚基进行了比较研究。进化数据为更好地理解健康和疾病中横纹肌收缩能力的细丝调节提供了有价值的信息。
The troponin complex plays a central role in regulating the contraction and relaxation of striated muscles. Among the three protein subunits of troponin, the calcium receptor subunit, TnC, belongs to the calmodulin family of calcium signaling proteins whereas the inhibitory subunit, TnI, and tropomyosin-binding/thin filament -anchoring subunit, TnT, are striated muscle-specific regulatory proteins. TnI and TnT emerged early in bilateral symmetric invertebrate animals and have co-evolved during the 500-700 million years of muscle evolution. To understand the divergence as well as conservation of the structures of TnI and TnT in invertebrate and vertebrate organisms adds novel insights into the structure-function relationship of troponin and the muscle type isoforms of TnI and TnT. Based on the significant growth of genomic database of multiple species in the past decade, this focused review studied the primary structure features of invertebrate troponin subunits in comparisons with the vertebrate counterparts. The evolutionary data demonstrate valuable information for a better understanding of the thin filament regulation of striated muscle contractility in health and diseases.