Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder
Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder
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DOI：
10.1002/hup.470
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发表时间：
2003-04-01
影响因子：
1.7
通讯作者：
Tezcan, E
中科院分区：
文献类型：
--
作者：
Atmaca, M;Kumru, S;Tezcan, E
临床试验证明，5-羟色胺再摄取抑制剂(SRIs)和蓖麻提取物对经前焦虑症(PMDD)有较好的疗效。然而，就我们所知，还没有研究比较SRIs和荆条提取物(AC)的疗效。因此，本研究的目的是比较选择性5-羟色胺再摄取抑制剂(SSRI)氟西汀和自然选择的AC提取物的疗效。经过2个月的筛选以筛选患者的适合性，41名符合DSM-IV的PMDD患者被纳入研究。这些患者被随机分为氟西汀或AC，为期2个月的单盲、评价者盲法和前瞻性治疗。结果测量包括宾夕法尼亚大学每日症状报告(DSR)、汉密尔顿抑郁量表(HAM-D)和临床总体印象-疾病严重程度(CGI-SI)和改善(CGI-I)量表。在终点，使用临床改善标准，患者对氟西汀(68.4%，n=13)和AC(57.9%，n=11)的反应百分比相似。在应答率方面，两组之间没有统计学上的显著差异。这项初步研究表明，PMDD患者对氟西汀和AC的治疗反应良好。然而，氟西汀对心理症状更有效，而提取物则减轻了身体症状。版权所有(C)2002 John Wiley Sons，Ltd.
Clinical trials have demonstrated that serotonin reuptake inhibitors (SRIs) and the extract of Vitex agnus castus are effective for the treatment of premenstrual dysphoric disorder (PMDD). However, to the best of our knowledge, there has been no study comparing the efficacy of the SRIs with Vitex agnus castus (AC) extract. Therefore, the aim of the present study was to compare the efficacy of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), with that of the AC extract, a natural choice. After a period of 2 screening months to screen the patients for suitability, 41 patients with PMDD according to DSM-IV were recruited into the study. The patients were randomized to fluoxetine or AC for 2 months of single-blind, rater-blinded and prospective treatment period. The outcome measures included the Penn daily symptom report (DSR), the Hamilton depression rating scale (HAM-D), and the clinical global impression-severity of illness (CGI-SI) and -improvement (CGI-I) scales. At endpoint, using the clinical criterion for improvement, a similar percentage of patients responded to fluoxetine (68.4%, n = 13) and AC (57.9%, n = 11). There was no statistically significant difference between the groups with respect to the rate of responders. This preliminary study suggests that patients with PMDD respond well to treatment with both fluoxetine and AC. However, fluoxetine was more effective for psychological symptoms while the extract diminished the physical symptoms. Copyright (C) 2002 John Wiley Sons, Ltd.