Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour
Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour
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DOI：
10.1093/brain/awg148
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发表时间：
2003-06-01
期刊：
影响因子：
14.5
通讯作者：
Rivaud-Pechoux, S
中科院分区：
文献类型：
--
作者：
Pierrot-Deseilligny, C;Müri, RM;Rivaud-Pechoux, S
三名单侧皮质病变影响背外侧前额皮质 (DLPFC)（即布罗德曼 46 区）的患者，使用不同的反射性扫视（间隙和重叠任务）、意向性扫视（反扫视、记忆引导和预测性扫视）和平滑追踪运动范例进行了测试。与对照组相比，具有间隙和重叠的视觉引导眼跳、正确反眼跳和记忆引导眼跳的潜伏期以及平滑追踪的增益均正常。这些结果证实了我们的解剖数据，即这些患者的邻近额眼视野 (FEF) 未受损。与之前报道的 FEF 损伤相比，单侧 DLPFC 损伤后的具体异常模式主要包括：（i）双侧抗眼跳任务中的错误百分比增加（误导性反射性眼跳）； (ii) 在记忆引导扫视任务中，幅度可变误差的双边增加，而增益没有显着下降； (iii) 预测任务中预期眼跳的双边百分比下降。总而言之，这些结果表明 DLPFC 在决策过程中发挥着至关重要的作用，根据当前的外部环境和内部情况，通过抑制不需要的反射性眼跳（抑制）、为持续的意向性眼跳（短期空间记忆）保留记忆信息或促进预期性眼跳（预测）来准备眼跳。
Three patients with a unilateral cortical lesion affecting the dorsolateral prefrontal cortex (DLPFC), i.e. Brodmann area 46, were tested using different paradigms of reflexive saccades (gap and overlap tasks), intentional saccades (antisaccades, memory-guided and predictive saccades) and smooth pursuit movements. Visually guided saccades with gap and overlap, latency of correct antisaccades and memory-guided saccades and the gain of smooth pursuit were normal, compared with controls. These results confirm our anatomical data showing that the adjacent frontal eye field (FEF) was unimpaired in these patients. The specific pattern of abnormalities after a unilateral DLPFC lesion, compared with that of the FEF lesions previously reported, consists mainly of: (i) a bilateral increase in the percentage of errors in the antisaccade task (misdirected reflexive saccades); (ii) a bilateral increase in the variable error in amplitude, without significant decrease in the gain, in the memory-guided saccade task; and (iii) a bilateral decrease in the percentage of anticipatory saccades in the predictive task. Taken together, these results suggest that the DLPFC plays a crucial role in the decisional processes, preparing saccades by inhibiting unwanted reflexive saccades (inhibition), maintaining memorized information for ongoing intentional saccades (short-term spatial memory) or facilitating anticipatory saccades (prediction), depending upon current external environmental and internal circumstances.