Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.
Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.
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DOI：
10.1001/jamapsychiatry.2014.3176
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发表时间：
2015-06
期刊：
影响因子：
25.8
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Mueller S;Wang D;Pan R;Holt DJ;Liu H
人类大脑的半球特化是成功神经发育的标志。在精神分裂症中反复报道的大脑不对称性改变可能代表了这种疾病中神经发育中断的后果。然而，精神分裂症患者大脑功能特化及其连接基质的全貌尚未揭开。我们的目的是量化内在的大脑半球专门化在皮层和皮层下水平，并揭示潜在的疾病影响精神分裂症。静息状态功能连接MRI此前已被用于以可靠的方式定量测量健康受试者的半球专业化。在这里，我们量化了31例精神分裂症患者和37例人口统计学匹配的健康对照组使用静息态功能连接MRI在全脑水平的内在半球专业化。尾状核和与尾状核相连的皮质区在精神分裂症患者中表现出明显异常的半球特化。与健康对照组相比，患者在左侧表现出较弱的专业化，但在右侧，尾状核相反的模式。精神分裂症患者还表现出与尾状核连接的皮质区域之间的半球间协调中断。基于尾状核的专门化的线性分类器以74%的分类准确率将患者与对照区分开。这些数据表明，大脑半球的专业化可以作为一个潜在的成像生物标志物的精神分裂症，相比基于任务的功能磁共振成像的措施，是不太容易混淆的影响，在任务的依从性，认知能力和命令的语言。
Hemispheric specialization of the human brain is a marker of successful neurodevelopment. Altered brain asymmetry that has been repeatedly reported in schizophrenia may represent consequences of disrupted neurodevelopment in the disorder. However, a complete picture of functional specialization in the schizophrenic brain and its connectional substrates are yet to be unveiled. We aimed to quantify intrinsic hemispheric specialization at a cortical and subcortical level and to reveal potential disease effects in schizophrenia. Resting-state functional connectivity MRI has been previously used to quantitatively measure hemispheric specialization in healthy subjects, in a reliable manner. Here we quantified the intrinsic hemispheric specialization at the whole brain level in 31 patients with schizophrenia and 37 demographically matched healthy control subjects using resting-state functional connectivity MRI. The caudate nucleus, and cortical regions with connections to the caudate nucleus, showed markedly abnormal hemispheric specialization in schizophrenia. Compared to healthy controls, patients exhibited weaker specialization in the left, but the opposite pattern in the right, caudate nucleus. Schizophrenia patients also displayed a disruption of the inter-hemispheric coordination among the cortical regions with connections to the caudate nucleus. A linear classifier based on the specialization of the caudate nucleus distinguished patients from controls with a classification accuracy of 74%. These data suggested that hemispheric specialization could serve as a potential imaging biomarker of schizophrenia that, compared to task-based fMRI measures, is less prone to the confounding effects of variation in task compliance, cognitive ability, and command of language.