DIETARY FIBERS, FIBER ANALOGS, AND GLUCOSE-TOLERANCE - IMPORTANCE OF VISCOSITY
DIETARY FIBERS, FIBER ANALOGS, AND GLUCOSE-TOLERANCE - IMPORTANCE OF VISCOSITY
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DOI：
10.1136/bmj.1.6124.1392
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
ALBERTI, KGMM
中科院分区：
文献类型：
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作者：
JENKINS, DJA;WOLEVER, TMS;ALBERTI, KGMM
为了确定在糖尿病治疗中最有潜力使用的膳食纤维或纤维类似物的类型，四到六名志愿者组成的小组进行了 50 克葡萄糖耐量测试 (GTT)，添加或不添加相当于 12 克纤维的瓜尔胶、果胶、黄芪胶、甲基纤维素、麦麸或考来烯胺。每种物质的添加均显着降低了 GTT 期间一个或多个点的血糖浓度，并且通常降低了血清胰岛素浓度。瓜尔胶的葡萄糖反应最平坦化，但当使用水解的非粘性瓜尔胶时，这种效果被消除。每种物质的血糖浓度平均峰值升高的降低与其粘度呈正相关（r = 0.926；P 小于 0.01），口腔到盲肠传输时间的延迟也是如此（r = 0.885；P 小于 0.02）。因此，粘性类型的膳食纤维最有可能在改变餐后高血糖方面具有治疗作用。
To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and without the addition of either guar, pectin, gum tragacanth, methylcellulose, wheat bran, or cholestyramine equivalent to 12 g fibre. The addition of each substance significantly reduced blood glucose concentration at one or more points during the GTT and generally reduced serum insulin concentrations. The greatest flattening of the glucose response was seen with guar, but this effect was abolished when hydrolysed non-viscous guar was used. The reduction in the mean peak rise in blood glucose concentration for each substance correlated positively with its viscosity (r = 0.926; P less than 0.01), as did delay in mouth-to-caecum transit time (r = 0.885; P less than 0.02). Viscous types of dietary fibre are therefore most likely to be therapeutically useful in modifying postprandial hyperglycaemia.