Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer.
Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer.
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血管生成参数在浸润性宫颈癌中的定量和预后相关性。
DOI：
10.1038/bjc.1998.460
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发表时间：
1998-07
影响因子：
8.8
通讯作者：
van Dam, P
中科院分区：
文献类型：
--
作者：
Tjalma, W;Van Marck, E;Weyler, J;Dirix, L;Van Daele, A;Goovaerts, G;Albertyn, G;van Dam, P
通过用特异性内皮标记物抗CD 31（克隆JC/70 A，同位素IgG 1）染色代表性切片，研究了114例浸润性和20例原位宫颈癌的肿瘤间质新生血管。使用数字图像分析仪测量免疫反应性。在“热点”中确定以下参数：血管计数、血管周长和内皮染色面积（以mm 2表示）。结果与临床和组织病理学数据相关。组织病理学结果（肿瘤组织学、肿瘤分化、FIGO分期、淋巴结转移或淋巴血管间隙受累）与中位血管计数之间无显著相关性。在单因素分析中，所有血管生成参数均具有预后价值：血管密度越高，预后越差（P < 0.05）。多因素回归分析显示，血管通透性（P < 0.001）和血管计数中位数（P = 0.005）是最重要的预后指标。在未来，这些标准可用于选择患者进行抗血管生成治疗。
Tumour stromal neovascularization was investigated in 114 invasive and 20 in situ carcinomas of the uterine cervix by staining representative sections with the specific endothelial marker anti CD31 (clone JC/70A, isotope IgG1). A digital image analyser was used to measure the immunoreactivity. The following parameters were determined in the 'hot spots': vessel counts, vessel perimeter and endothelial stained area (expressed per mm2). The results were correlated with clinical and histopathological data. There was no significant relationship between the histopathological findings (tumour histology, tumour differentiation, FIGO stage, presence of lymph node metastasis or lymphovascular space involvement) and the median vessel count. In a univariate analysis all angiogenesis parameters had prognostic value: a higher vascularity was associated with worse prognosis (P < 0.05). Multiple regression analysis showed that vascular permeation (P < 0.001) and the median vessel count (P = 0.005) were the most important prognostic indicators. In the future these criteria may be used for selection of patients for anti-angiogenesis therapy.