One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko
One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko
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来自担子菌滑菇培养物的一种新的萜烯倍半萜
DOI：
10.1080/14786419.2019.1586694
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发表时间：
2019-03-12
影响因子：
2.2
通讯作者：
Yang, Xiao-Yan
中科院分区：
文献类型：
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作者：
Niu, Wan-Rong;Guo, Cong-Liang;Yang, Xiao-Yan
摘要从担子菌Pholiota nameko的培养物中分离得到一个新的甾杂环倍半萜(1)，命名为(3R，6S，7S，8R，10S)-3，7，14-trihydroxy-1-sterpurene。新化合物的结构经广谱确证。此外，单晶X射线衍射仪不仅确认了该化合物的结构，而且确定了该化合物的绝对构型。该化合物对五种人类癌细胞株的细胞毒性进行了评估，但没有发现明显的细胞毒性(IC50值和GT；40 μM)。图形摘要
Abstract One new sterpurane sesquiterpene (1), named (3R,6S,7S,8R,10S)-3,7,14-trihydroxy-1-sterpurene was isolated from cultures of the basidiomycete Pholiota nameko. The structure of new compound was elucidated by extensive spectroscopic. Additionally, a single crystal X-ray diffraction not only confirmed the structure, but also determined the absolute configuration of the new compound. The compound was evaluated for cytotoxicity against five human cancer cell lines, but no significant cytotoxicity were found (IC50 values > 40 μM). Graphical Abstract