Chemokines in cancer.
Chemokines in cancer.
复制标题
DOI：
10.1017/s1462399401003301
复制
发表时间：
2001-07-18
影响因子：
6.2
通讯作者：
Clayman, G L
中科院分区：
文献类型：
--
作者：
Frederick, M J;Clayman, G L
趋化因子是一种小的趋化细胞因子，可引导白细胞迁移，激活炎症反应并参与许多其他多效功能，包括调节肿瘤生长。趋化因子通过三个重要机制调节肿瘤行为：肿瘤相关血管生成的调节，宿主肿瘤特异性免疫反应的激活，以及以自分泌方式直接刺激肿瘤细胞增殖。所有这些机制都是癌症干预的有希望的点，临床前小鼠模型表明趋化因子拮抗剂和激动剂可能在开发新的抗癌疗法中变得重要。
Chemokines are small, chemotactic cytokines that direct migration of leukocytes, activate inflammatory responses and participate in many other pleiotropic functions, including regulation of tumour growth. Chemokines modulate tumour behaviour by three important mechanisms: regulation of tumour-associated angiogenesis, activation of a host tumour-specific immunological response, and direct stimulation of tumour cell proliferation in an autocrine fashion. All of these mechanisms are promising points of cancer intervention, and preclinical mouse models suggest that chemokine antagonists and agonists could become important in the development of new anticancer therapies.