A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: Evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy
A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: Evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy
复制标题
DOI：
10.1002/art.20405
复制
发表时间：
2004-06-15
期刊：
影响因子：
--
通讯作者：
Kamatani, N
中科院分区：
文献类型：
--
作者：
Shoji, A;Yamanaka, H;Kamatani, N
目标。评估持续降低血尿酸至亚饱和范围与降低急性痛风发作次数之间的关系。我们回顾了来自267名患者的数据，这些患者在第一次来我们诊所之前经历过至少一次痛风发作。从每个患者第一次就诊起，在长达3年的每次就诊中收集血尿酸浓度、反复痛风发作的病史和抗高尿酸血症药物使用的信息。对入组1年后的访视资料进行统计分析。在研究开始前调整基线血尿酸水平和痛风发作次数后，降低随访血尿酸浓度和使用抗高尿酸血症药物均显著降低痛风发作的风险(优势比[OR]0.42，95%可信区间[95%CI]0.31~0.57；OR 0.22，95%CI 0.10~0.47)。数据表明，将血尿酸浓度降低到6 mg/dl或更低，最终将导致痛风发作的频率减少或防止未来的痛风发作。
Objective. To evaluate the proposed relationship between persistent reduction of serum urate into the subsaturating range and reduction in the frequency of acute gouty attacks.Methods. We retrospectively examined data derived from 267 patients who had experienced at least 1 gouty attack before their first visit to our clinic. Serum urate concentration, history of recurrent gouty attacks, and information about antihyperuricemic drug use were collected on each visit for up to 3 years from the first visit of each patient. Data derived from visits >1 year after study entry were subjected to statistical analysis.Results. When adjusted for baseline serum urate level and the number of gouty attacks prior to study entry, reduction of followup serum urate concentration and antihyperuricemic drug use were each significantly associated with a reduced risk of gouty attacks (odds ratio [OR] 0.42, 95% confidence interval [95% CI] 0.31-0.57; OR 0.22, 95% CI 0.10-0.47, respectively).Conclusion. The data indicate that reduction of serum urate concentrations to 6 mg/dl or lower will eventually result in a reduced frequency or prevention of future gouty attacks.