RECOVERY OF SKILLED MOTOR FUNCTIONS AFTER SMALL REPEATED LESIONS OF MOTOR CORTEX IN MACAQUE
RECOVERY OF SKILLED MOTOR FUNCTIONS AFTER SMALL REPEATED LESIONS OF MOTOR CORTEX IN MACAQUE
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DOI：
10.1152/jn.1950.13.2.137
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发表时间：
1950-01-01
影响因子：
2.5
通讯作者：
COLE, J
中科院分区：
文献类型：
--
作者：
GLEES, P;COLE, J
在恒河猴的拇指区域或运动皮层的其他小部分所做的损伤表明，通过马奇技术，在内囊内没有明确的区域可以分配给皮质-脊髓纤维，这些纤维来自一个明确划分的区域4。我们还观察到纤维从拇指区域向下延伸到脊髓的腰椎区域。运动皮质拇指区域的小病变产生对侧短暂性麻痹。麻痹本身及其逐渐和几乎完全的恢复都是通过作者的“火柴盒抽屉技术”进行定量测量的，而通过他们与训练有素的猴子一起工作的问题盒进行定性测量的。当恢复发生时，再次暴露皮质，发现先前病变附近的区域产生了第一次手术无法获得的拇指反应。这些部位的损伤导致瘫痪复发，虽然恢复了一些，但失去了更精细的动作。这些发现表明，受伤的运动皮层的功能并不遵循马赛克模式，如果特定功能的永久缺失是在有限的损伤之后发现的。相反，倾向于保持肢体或多或少完整的功能。这种现象可以用“接管”的内在能力来解释，这种能力潜伏在未受伤的运动皮层部分，其解剖学途径已经得到证实。
Lesions made in the thumb area or other small parts of the motor cortex of Rhesus monkeys revealed that by the Marchi technic no definite area within the internal capsule can be assigned to the cortico-spinal fibers coming from a well defined division of area 4. It was also observed that fibers descended from the thumb area down to the lumbar region of the cord. The small lesions in the thumb area of the motor cortex produced con-tralateral transient paralysis. Both the paralysis itself and its gradual and almost complete recovery were measured quantitatively by the authors'' match box drawer technic and qualitatively by their problem box working with trained monkeys. When recovery had taken place the cortex was again exposed and areas adjacent to the previous lesion were found to yield thumb responses which were not obtainable at the first operation. Undercutting of these areas resulted in a recurrence of the paralysis, from which some recovery occurred, but the more delicate movements were lost. These findings suggest that the function of the injured motor cortex does not follow a mosaic like pattern as would be revealed if the permanent absence of particular functions followed circumscribed lesions. On the contrary, the tendency is to maintain a more or less complete functioning of the limb. This phenomenon may be explained by the inherent ability of "taking over" which is latent in uninjured parts of the motor cortex and for which anatomical pathways have been demonstrated.