Efficient production of high specific activity Cu-64 using a biomedical cyclotron
Efficient production of high specific activity Cu-64 using a biomedical cyclotron
复制标题
DOI：
10.1016/s0969-8051(96)00157-6
复制
发表时间：
1997-01-01
影响因子：
3.1
通讯作者：
Welch, MJ
中科院分区：
文献类型：
--
作者：
McCarthy, DW;Shefer, RE;Welch, MJ
铜-64（T-1/2 = 12.7 h）是一种中等寿命的正电子发射放射性核素，其是用于正电子发射断层扫描（PET）的有用的放射性示踪剂以及用于治疗癌症的有前景的放射治疗剂。目前，适用于生物医学研究的铜-64是在密苏里州大学研究反应堆的快中子通量阱（用快中子照射锌）中生产的。快中子通量阱只能每周使用一次，因此这种示踪剂的可用性非常有限。为了大幅度提高中寿命放射性示踪剂Cu-64的利用率，我们研究并发展了一种利用小型生物医用回旋加速器高效生产高比活度Cu-64的方法，提出了利用Ni-64（p，n）（CU）-C-64核反应在小型生物医用回旋加速器上生产Cu-64的可能性。我们辐照了天然镍和镀在金盘上的富集（95%和98%）Ni-64。镍已成功地电镀在类似的厚度为20-300毫米和轰击的质子电流为15-45 μ A的特殊水冷靶已被设计，以促进生物医学回旋加速器上的辐射高达60 μ A。我们已经表明，它是可能的分离Cu-64从Ni-64和其他反应副产物快速和有效地通过使用离子交换色谱。使用19-55 mg 95%富集的Ni-64的生产运行产生了150-600 mCi的Cu-64（2.3-5.0 mCi/mu Ah），比活度为94-310 mCi/mu g Cu。回旋加速器产生的Cu-64已用于放射性标记PTSM [双-（N-4-甲基缩氨基硫脲），用于定量心肌、脑、肾和肿瘤血流量]、MAb 1A 3 [抗结肠癌单克隆抗体MAb]和奥曲肽。研究了一种昂贵的Ni-64靶材的回收技术。该技术允许从柱上洗脱的镍被回收并重新用于电镀新靶，总效率大于90%。版权所有（C）1997 Elsevire Science Inc.
Copper-64 (T-1/2 = 12.7 h) is an intermediate lived positron emitting radionuclide that is a useful radiotracer for positron emission tomography (PET) as well as a promising radiotherapy agent for the treatment for cancer. Currently, copper-64 suitable for biomedical studies is produced in the fast neutron flux trap (irradiation of zinc with fast neutrons) at the Missouri University Research Reactor. Access to the fast neutron flux trap is only possible on a weekly basis, making the availability of this tracer very limited. In order to significantly increase the availability of this intermediate-lived radiotracer, we have investigated and developed a method for the efficient production of high specific activity Cu-64 using a small biomedical cyclotron.It has been suggested that it may be possible to produce Cu-64 on a small biomedical cyclotron utilizing the Ni-64(p,n)(CU)-C-64 nuclear reaction. We have irradiated both natural nickel and enriched (95% and 98%) Ni-64 plated on gold disks. Nickel has been electroplated successfully at thicknesses of similar to 20-300 mm and bombarded with proton currents of 15-45 mu A A Special water-cooled target had been designed to facilitate the irradiations on a biomedical cyclotron up to 60 mu A.We have shown that it is possible to separate Cu-64 from Ni-64 and other reaction byproducts rapidly and efficiently by using ion exchange chromatography. Production runs using 19-55 mg of 95% enriched Ni-64 have yielded 150-600 mCi of Cu-64 (2.3-5.0 mCi/mu Ah) with specific activities of 94-310 mCi/mu g Cu. The cyclotron produced Cu-64 had been used to radiolabel PTSM [pyruvaldehyde bis-(N-4- methylthiosemicarbazone), used to quantify myocardial, cerebral, renal, and tumor blood flow], MAb 1A3 [monoclonal antibody MAb to colon cancer], and octreotide. A recycling technique for the costly Ni-64 target material has been developed. This technique allows the nickel eluted off the column to be recovered and reused in the electroplating of new targets with an overall efficiency of greater than 90%. Copyright (C) 1997 Elsevire Science Inc.