A population-based study of cardiovascular diseasemortality risk in US cancer patients
A population-based study of cardiovascular diseasemortality risk in US cancer patients
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DOI：
10.1093/eurheartj/ehz766
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发表时间：
2019-12-21
影响因子：
39.3
通讯作者：
Zaorsky, Nicholas G.
中科院分区：
文献类型：
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作者：
Sturgeon, Kathleen M.;Deng, Lei;Zaorsky, Nicholas G.
这项观察性研究的特征是多个癌症部位的心血管疾病（CVD）死亡风险，涉及以下方面：（i）连续历年，（ii）诊断时的年龄，和（iii）诊断后的随访时间。方法和结果监测，流行病学，和最终结果计划用于比较美国普通人群与3，234，256名美国癌症幸存者（1973-2012）。使用编码的心血管疾病死亡原因（心脏病、高血压、脑血管疾病、动脉粥样硬化和主动脉瘤/夹层）计算标准化死亡率（SMR）。根据年龄、种族和性别调整分析。在28种癌症类型中，1228328例患者（38.0%）死于癌症，365689例患者（11.3%）死于心血管疾病。在心血管疾病中，76.3%的死亡是由于心脏病。在八个癌症站点中，CVD死亡风险在至少一个日历年中超过了指数癌症死亡风险。心血管疾病死亡风险最高的幸存者诊断为
Aims This observational study characterized cardiovascular disease (CVD) mortality risk for multiple cancer sites, with respect to the following: (i) continuous calendar year, (ii) age at diagnosis, and (iii) follow-up time after diagnosis.Methods and results The Surveillance, Epidemiology, and End Results program was used to compare the US general population to 3 234 256 US cancer survivors (1973-2012). Standardized mortality ratios (SMRs) were calculated using coded cause of death from CVDs (heart disease, hypertension, cerebrovascular disease, atherosclerosis, and aortic aneurysm/ dissection). Analyses were adjusted by age, race, and sex. Among 28 cancer types, 1 228 328 patients (38.0%) died from cancer and 365 689 patients (11.3%) died from CVDs. Among CVDs, 76.3% of deaths were due to heart disease. In eight cancer sites, CVD mortality risk surpassed index-cancer mortality risk in at least one calendar year. Cardiovascular disease mortality risk was highest in survivors diagnosed at