The association between gut butyrate-producing bacteria and non-small-cell lung cancer
The association between gut butyrate-producing bacteria and non-small-cell lung cancer
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DOI：
10.1002/jcla.23318
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发表时间：
2020-03-29
影响因子：
2.7
通讯作者：
Xiao, Chi
中科院分区：
文献类型：
--
作者：
Gui, Qifeng;Li, Hanyu;Xiao, Chi
近期研究发现，肠道菌群可能通过“肠-肺轴”影响肺癌的发生发展。为了研究这种关系，我们进行了这项研究，以确定非小细胞肺癌（NSCLC）患者的肠道微生物群是否与健康成人不同。方法采用定量PCR （qPCR）检测健康成人和非小细胞肺癌患者肠道中8种产丁酸菌的表达水平。在年龄和性别匹配后，我们从100名健康成人中招募了30名非小细胞肺癌患者和30名受试者。结果与健康成人相比，非小细胞肺癌患者肠道中大部分产丁酸菌明显减少；其中包括prausnitzii粪杆菌、瘦梭菌、梭菌群I、Ruminococcus spp、Clostridial cluster XIVa和Roseburia spp.在肠道产生丁酸盐的细菌中，我们分析了梭菌群IV和直肠真杆菌在NSCLC患者中没有减少。结论：非小细胞肺癌患者存在肠道产丁酸菌失调。应该进行进一步的研究来调查这些特定细菌如何影响肺癌进展和预后的潜在机制。
Background Recently, it has been found that the gut microbiota may affect the development of lung cancer through the "gut-lung axis." To investigate this relationship, we performed this study to determine whether the gut microbiota in non-small-cell lung cancer (NSCLC) patients is different from that in healthy adults.Methods Quantitative PCR (qPCR) was used to detect the expression levels of eight gut butyrate-producing bacteria in healthy adults and NSCLC patients. We enrolled 30 patients with NSCLC and 30 subjects from 100 healthy adults after matching for age and sex.Results Compared to healthy adults, most of the gut butyrate-producing bacteria in NSCLC patients were significantly decreased; these included Faecalibacterium prausnitzii, Clostridium leptum, Clostridial cluster I, Ruminococcus spp., Clostridial Cluster XIVa, and Roseburia spp. Among the gut butyrate-producing bacteria, we analyzed Clostridial cluster IV and Eubacterium rectale were not decreased in NSCLC patients.Conclusions We conclude that NSCLC patients had gut butyrate-producing bacteria dysbiosis. Further studies should be performed to investigate the underlying mechanisms of how these specific bacteria affect lung cancer progression and prognosis.