Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide.
Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide.
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肽YY和胰多肽对大鼠外分泌胰腺的抑制性调节。
DOI：
10.1152/ajpgi.1989.256.4.g698
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Williams,JA
中科院分区：
文献类型：
--
作者：
Putnam,WS;Liddle,RA;Williams,JA
肽YY（PYY）和胰多肽（PP）已显示在多种物种中在体内抑制胰腺外分泌。本研究通过在麻醉大鼠中检查胆囊收缩素（CCK）、2-脱氧-D-葡萄糖（2DG）、氨甲酰胆碱和迷走神经电刺激对胰腺分泌的抑制作用，评价PYY和PP抑制的刺激类型。PYY在最大输注速率下抑制CCK刺激的83%，抑制氨甲酰胆碱刺激的55%，抑制电神经刺激的40%。250 pmol·kg ~（-1）·h ~（-1）时，CCK刺激的抑制达到最大值的一半。相比之下，PYY完全抑制2DG刺激的分泌，在10 pmol时具有半数最大抑制。kg-1.h-1. PP在抑制CCK和2DG刺激的胰腺蛋白分泌方面的作用与PYY相似，但在每种情况下都弱五倍。这些结果表明，PYY和PP有多种作用，但优先抑制神经介导的胰腺分泌的前腺泡细胞位点，可能在一个中央网站的行动。
Peptide YY (PYY) and pancreatic polypeptide (PP) have been shown to inhibit exocrine pancreatic secretion in vivo in a variety of species. This study evaluates the type of stimulation inhibited by PYY and PP by examining, in urethan-anesthetized rats, the inhibition of pancreatic secretion when stimulated to a comparable extent by cholecystokinin (CCK), 2-deoxy-D-glucose (2DG), bethanecol, and electrical vagal nerve stimulation. PYY at maximal infusion rates inhibited stimulation by CCK by 83%, bethanecol by 55%, and electrical nerve stimulation by 40%. The inhibition of CCK stimulation was half maximal at 250 pmol.kg-1.h-1. By contrast, PYY totally inhibited 2DG-stimulated secretion with half-maximal inhibition at 10 pmol. kg-1.h-1. PP acted similarly to PYY in inhibiting CCK and 2DG-stimulated pancreatic protein secretion but was fivefold weaker in each case. These findings indicate that PYY and PP have multiple actions but preferentially inhibit neurally mediated pancreatic secretion at a preacinar cell locus, possibly at a central site of action.